食管鳞状细胞癌中TWIST1对上皮间质转化的调控  

Regulation of epithelial-mesenchymal transition by TWIST1 in esophageal squamous cell carcinoma

作　　者：陈海生[1] 王平[1] 陆松华[1] 

机构地区：[1]南通大学附属海安医院胸外科,江苏省226600

出　　处：《江苏医药》2017年第4期257-258,F0002,共3页Jiangsu Medical Journal

摘　　要：目的探讨食管鳞状细胞癌(ESCC)组织中TWIST1对上皮间质转化(EMT)相关蛋白的调控作用。方法采用免疫组化法检测50例ESCC组织中TWIST1、上皮钙黏蛋白(EC)、神经钙黏蛋白(NC)和波形蛋白(V)的表达,分析TWIST1与EC、NC、V之间的关系。结果 TWIST1、EC、NC和V在ESCC组织中的阳性表达率分别为50.0%、38.0%、48.0%和52.0%。ESCC组织中TWIST1表达与EC表达呈负相关(r=-0.371,P<0.01),与V表达呈正相关(r=0.480,P<0.01),而与NC不存在明显相关性(r=0.240,P>0.05)。结论 TWIST1在ESCC中可能通过抑制EC表达、上调V表达而参与EMT过程的调节。Objective To investigate the regulatory effect of TWIST1 on epithelial-mesenchymal transition（EMT）-related proteins in esophageal squamous cell carcinoma（ESCC）.Methods The expressions of TWIST1,E-cadherin（EC）,N-cadherin（NC）and vimentin（V）were detected by immunohistochemistry in 50 cases of ESCC.The relationship of TWIST1 with EC,NC and V was analyzed.Results The positive expression rates of TWIST1,EC,NC and V in ESCC tissues were50.0%,38.0%,48.0% and 52.0%,respectively.TWIST1 expression in ESCC was negatively correlated with EC expession（r=-0.371,P〈0.01）,positively correlated with V expression（r=0.480,P〉0.01）,but not relevant to NC（r=0.240,P〈0.05）.Conclusion TWIST1 plays a regulatory role in the process of EMT probably via inhibiting EC expression and increasing V expression.

关 键 词：上皮间质转化 食管鳞状细胞癌 TWIST1 

分 类 号：R735[医药卫生—肿瘤]