神经母细胞瘤中N-myc的作用机制研究进展  

Research Progress of Underlying Mechanism of N-myc in Neuroblastoma

作　　者：赖祥萍 赖天霞[1] 廖伟[1] 

机构地区：[1]第三军医大学西南医院儿科,重庆400038

出　　处：《医学综述》2017年第5期926-930,共5页Medical Recapitulate

摘　　要：神经母细胞瘤(NB)是儿童期最常见的颅外实体肿瘤,来源于交感神经系统。MYCN基因扩增是目前公认的NB不良预后的标志,该基因在约20%的NB患者中发生扩增或过表达。MYCN基因编码的转录因子N-myc通过调控NB细胞中p53、S期相关蛋白激酶2、鸟氨酸脱羧酶1、双微体2等多种分子的表达以及非编码RNA,调节细胞周期、分化以及凋亡等,进而促进NB演进。对N-myc作用机制的研究将有助于开发治疗NB的新药,以期给患者的治疗带来希望。Neuroblastoma（NB） is the most common extracranial solid tumor of young children, arising from the embry- onic sympathetic system. Amplification or over-expression of MYCN gene occurs in 20% NB tissues and predicts poor prog- nosis of NB patients. MYCN gene codes N-myc, which regulates cell cycle, differentiation and apoptosis by regulating mole- cute expression like p53, S-phase associated kinase 2, ornithine decarboxylase 1, murine double minute 2 and non-coding RNA, and promotes NB development. Studying the mechanism of action is helpful to the development of new drugs for NB treatment and will bring hope to the patients.

关 键 词：神经母细胞瘤 N-MYC 增殖 分化 凋亡 

分 类 号：R739.4[医药卫生—肿瘤]