酒精性肝硬化患者常见血清学指标分析  

Clinical serological parameters in patients with alcoholic cirrhosis with or without ascites

作　　者：赵亚楠[1] 曹姗姗[1] 李红[1] Zhao Yanan Cao Shanshan Li Hong.(Department of Infectious Disease,First Hospital,Affiliated to Shanxi Medical University, Taiyuan 030001 ,Shanxi Province, China)

机构地区：[1]山西医科大学第一医院感染病科,太原市030001

出　　处：《实用肝脏病杂志》2017年第2期183-186,共4页Journal of Practical Hepatology

摘　　要：目的分析酒精性肝硬化(AC)患者常见临床检测指标的特点。方法我科自2012年1月~2016年9月收治住院的AC患者103例,其中无腹水患者33例,有腹水患者70例。收集临床常规检测的血清学、血常规和肿瘤标志物结果,采用t检验或Mann-Whitney U检验。结果 AC患者以男性为主,40~60岁为好发年龄;无腹水的AC患者血清PT-S、APTT、TT、INR、D-h分别为(17.5±3.5)s、(33.3±4.6)s、(17.0±1.9)s、(1.3±0.3)和(749.8±1246.9)μg/L,显著低于有腹水的AC患者[分别为(22.3±7.2)s、(39.2±10.5)s、(19.1±4.7)s、(1.7±0.7)和(1330.4±1402.4)μg/L,P<0.05];无腹水组血清ALB、RBC、HGB分别为(35.1±5.2)g/L、(3.6±0.9)×1012/L和(120.7±30.0)g/L,显著高于有腹水组[分别为(30.6±6.2)g/L、(3.0±0.8)×1012/L和(101.7±30.1)g/L,P<0.05];无腹水组血清肿瘤标志物CA125为(93.4±128.4)U/ml,显著低于有腹水组[(468.1±498.4)U/ml,P<0.05]。结论有无腹水的AC患者血常规、生化和肿瘤标志物可能存在差异,定期对PT-S、APTT、TT、INR、D-h、ALB、RBC、HGB及肿瘤标志物等指标进行检测,或许能帮助监测病情变化。Objective To analyze serum biochemical indexes of patients with alcoholic cirrhosis （AC） with or without ascites. Methods A total of 103 patients with AC were chosen in our hospital between January 2012 and September 2016. There were 33 patients without,and 70 with ascites. The clinical datas of demographics, coagulation function, liver function, routine blood tests, and tumor markers were collected, and analyzed by Student＇s t or Mann-Whitney U tests. Result The majority of patients with AC were man with the peak of incidence in the age from 40 to 60 years old. serum levels of PT-S,APTT,TT,INR and D-h in AC patients without aseites were （17.5±3.5） s, （33.3±4.6） s, （17.0±1.9） s, （1.3±0.3） and （749.8±1246.9） μg/L, respectively,much lower than those in with ascites [（22.3±7.2） s,（39.2±10.5） s,（19.1±4.7） s,（1.7±0.7） and （1330.4±1402.4） μg/L,respeetively,P〈0.05];serum levels of ALB and blood RBC and HGB in AC patients without aseites were （35.1±5.2） g/L,（3.6±0.9）×10^/L and （120.7±30.0） g/L,respectively,much higher than those in with aseites [（30.6±6.2） g/L,（3.0±0.8）×10^12/L and （101.7±30.1） g/L,respectively,P〈0.05];serum levels of CA125 in AC patients without ascites was （93.4±128.4） U/ml, much lower than that in aseites group [（468.1± 498.4） U/ml, P〈0.05]. Conclusion There might exist differences between serum and blood parameters in patients with AC with and without aseites,whieh warrants surveillance of them in evaluating disease severity.

关 键 词：酒精性肝硬化 腹水 血清学指标 

分 类 号：R575.2[医药卫生—消化系统]