血管内皮细胞中的凝血物质:理论研究新进展  

Advances in theoretical studies on coagulating substances secreted by vascular endothelial cells

作　　者：叶梓[1] 王世杰[2] 李辉 刘璐[4] Ye Zi Wang Shi-jie Li Hui Liu Lu(Pharmacy 131, First Battalion of Cadet Second Bridage, Logistic University of Chinese Armed Police, Tianjin 300309, China Rescue 131, Seventh Battalion of Cadet Second Bridage, Logistic University of Chinese Armed Police, Tianjin 300309, China Medical Corp of Tongchuan Branch of Shaanxi General Corp of Chinese Armed Police, Tongchuan 727100, Shaanxi Province, China Department of Chemistry, Logistic University of Chinese Armed Police, Tianjin 300309, China)

机构地区：[1]武警后勤学院学员二旅一营药学131,天津市300309 [2]武警后勤学院学员二旅七营救援131,天津市300309 [3]武警陕西总队铜川支队卫生队,陕西省铜川市727100 [4]武警后勤学院化学教研室,天津市300309

出　　处：《中国组织工程研究》2017年第4期627-632,共6页Chinese Journal of Tissue Engineering Research

基　　金：天津市应用基础与前沿技术研究计划一般项目(15JCYBJC18600)~~

摘　　要：背景:血管内皮细胞在凝血过程中能够分泌众多凝血物质参与凝血级联反应或收缩血管促进凝血进程。目的:综述血管内皮细胞分泌的不同凝血物质的作用机制,为凝血功能材料的筛选提供理论依据。方法:应用计算机检索中国知网、Pub Med数据库1988至2016年收录的与血管内皮细胞凝血物质相关的文献。英文检索词为"Vascular endothelial cells,endothelin,AngⅡ,TXA2,tissue factor,Collagen,fibronectin,von wilbrand factor,thrombospondin,platelet activating factor,plasminogen activator inhibitor,proaccelerin,antihemophlic factor",中文检索词为"血管内皮细胞,组织因子,胶原,纤维连接蛋白,血小板激活因子,纤溶酶原激活物抑制物,凝血因子Ⅴ、Ⅷ,内皮素,血管紧张素Ⅱ,血栓素",最终纳入文献38篇进行综述。结果与结论:血管损伤时血管内皮细胞产生的众多凝血因子在凝血、炎症反应以及血栓形成过程中发挥着重要的作用。凝血过程中,血管内皮细胞分泌众多促凝因子和凝血因子Ⅴ和Ⅷ直接参与凝血级联瀑布反应,促进血栓形成;同时血管内皮细胞分泌的收缩血管因子使血管腔狭小,辅助凝血过程,间接促进血栓形成。BACKGROUND： Vascular endothelial cells participate in the coagulation cascade reaction or contraction of blood vessels by secreting abundant coagulating substances that promote coagulation. OBJECTIVE： To overview the effects of different coagulating substances secreted by vascular endothelial cells, and provide theoretical basis for the screening of coagulant biomaterials.METHODS： A computer-based research in CNKI and Pub Med databases was performed for relevant literatures addressing vascular endothelial cells and its secreting coagulating substances published from 1988 to 2016 usingthe keywords of ＂vascular endothelial cells, endothelin, Ang II, TXA2, tissue factor, collagen, fibronectin, von wilbrand factor, thrombospondin, platelet activating factor, plasminogen activator inhibitor, proaccelerin, antihemophlic factor＂ in English and Chinese, respectively. Finally 36 articles were enrolled for result analysis. RESULTS AND CONCLUSION： Vascular endothelial cells can secrete numerous coagulation factors that play important roles in the process of coagulation, inflammation reaction and thrombosis following vascular injury. Among them, coagulation factor V and VIII are directly involved in the coagulation cascade reaction and promote thrombosis. In the meanwhile, the vasoconstrictors narrow the lumen, thereby assisting coagulation and promoting thrombosis indirectly.

关 键 词：内皮细胞 血液凝固因子 内皮缩血管肽类 组织工程 组织构建 血管内皮细胞 促凝因子 血管收缩因子 

分 类 号：R394.2[医药卫生—医学遗传学]