硕苞蔷薇儿茶素对铝超载小鼠学习记忆能力的影响  

Improvement of Catechin on Learning and Memory Impairment Induced by Aluminum in Mice

作　　者：冯星[1] 许东晖[1] 梅雪婷[1] 朱良[1] 许实波[1] 

机构地区：[1]中山大学药学系药物药理研究室,广州510275

出　　处：《中国药科大学学报》2002年第4期321-325,共5页Journal of China Pharmaceutical University

基　　金：国家自然科学基金课题 (3 0 170 10 5 )

摘　　要：目的　从中药苞蔷薇根中提取的化学成分硕苞蔷薇 (+) -儿茶素 ((+) -Catechin,CAT) ,通过铝超载模型来研究 CAT对铝中毒小鼠学习记忆能力的影响。方法　在小鼠的饮水和饲料中添加铝来造成小鼠体内铝超载 ,给药组在造模的同时给予 CAT或去铁胺 (desferrioxamine methane sulphonate,DFO) ,4周后 ,观察各组小鼠的学习记忆能力。并取血、脑和肾来测定血清和组织匀浆中 SOD、MDA、MAO-B变化的水平。结果　CAT能非常显著地改善铝超载小鼠的记忆能力 ;非常显著地提高血清、脑和肾组织匀浆中的 SOD水平 ,降低血清、脑和肾组织匀浆中的 MDA的生成 ,降低脑中的 MOA-B的水平。结论　CAT能改善铝超载所致的小鼠学习记忆障碍 。AIM To investigate the improvement of catechin(CAT), which is extracted from \%Rosa bracteata\% Wendl, a Chinese traditional medicine, on the learning and memory impairment induced by aluminum in mice. METHODS Al\-2(SO\-4)\-3 was added to the water and food of mice to make them Al overloaded, and CAT was given to the mice at the same time. After 4 weeks, we used the step down test, step through test, and 'Y' maze test to investigate the improvement. SOD?MDA of the serum, brain and kidney and the MOA B of brain were measured. RESULTS It was found that CAT could improve the ability of learning and memory of the Al overloaded mice, raise the content of SOD of serum, brain and kidney, restrain the makeup of MDA in serum?brain and kidney, and lower the level of MOA B in brain. CONCLUSION It was suggested that CAT could improve the ability of learning and memory to the Al overloaded mice and have a strong effect of anti oxygen.

关 键 词：硕苞蔷薇儿茶素 铝超载 小鼠 学习记忆能力 抗氧化能力 

分 类 号：R285.5[医药卫生—中药学]