肝炎肝硬化骨髓血细胞形态学改变对LDH活性的影响  

Effect of Bone Marrow Blood Cell Morphology Changes on LDH Activity in Patients with Hepatitis Cirrhosis

作　　者：景晔[1] 徐和福[1] 陆光生[1] 吴少华[1] 

机构地区：[1]北京军区天津疗养院检验科,天津300381

出　　处：《中国医药导刊》2017年第2期188-189,192,共3页Chinese Journal of Medicinal Guide

摘　　要：目的:探讨肝炎肝硬化患者骨髓血细胞形态学改变与乳酸脱氢酶(LDH)水平高低的相关性及其临床意义。方法:对104例失代偿期肝炎肝硬化患者骨髓血细胞形态学、血清谷丙转氨酶(ALT)、乳酸脱氢酶进行统计分析。结果:肝炎肝硬化患者骨髓三系血细胞均出现不同程度病态造血,即三系血细胞均呈现成熟障碍,三系血细胞病态造血与血清乳酸脱氢酶升高呈正相关,P均<0.05,尤以红系为最明显。结论:乳酸脱氢酶活性进行性升高反映了骨髓血细胞与外周血细胞转换的增高以及肝脏损害加重和脾脏功能亢进,代表了一种病态造血的简易准确检测方法及判断预后因素。Objective：In order to further explore the correlation between the morphological changes of bone marrow blood cells and the level of lactate dehydrogenase（LDH） in patients with hepatitis cirrhosis and its clinical significance.Methods：The morphology of bone marrow,serum alanine aminotransferase（ALT） and lactate dehydrogenase were analyzed in 104 patients with cirrhosis of the liver loss compensation period.Results：The three blood cells in the bone marrow of patients with cirrhosis of the liver and liver cirrhosis had different degrees of pathological hematopoiesis,namely three lines of blood cells showed mature barriers,Three blood cells pathological blood and serum lactate dehydrogenase increased positive correlation,P〈0.05,especially the red system was the most obvious.Conclusion：The increase of LDH activity reflected the increase of bone marrow blood cells and peripheral blood cells transformation,and the degree of liver damage and spleen function.A simple and accurate method for the detection of dyshaematopoiesis and prognostic factors.

关 键 词：肝炎肝硬化 病态造血 血细胞 骨髓 乳酸脱氢酶 

分 类 号：R575[医药卫生—消化系统]