结肠癌组织中 BRG1的表达及其与病理分级、临床病理分期的相关性  

Expression of BRG1 in colon cancer and its relationship with histological grade and clinicopathological stages characteristics

作　　者：邱磊[1] 邵华[1] 邓建武[1] 苗永昌[1] Qiu Lei Shao Hua Deng Jianwu Miao Yongchang(Department of Gastrointestinal Surgery, the Second People＇s Hospital of Lianyungang , Lianyungang , Jiangsu 222006, Chin)

机构地区：[1]连云港市第二人民医院胃肠外科,江苏省连云港222006

出　　处：《中国基层医药》2017年第5期683-685,J0001,共4页Chinese Journal of Primary Medicine and Pharmacy

基　　金：江苏省连云港市卫生局科研项目（局1413）;江苏省连云港市“521工程”资助项目

摘　　要：目的：观察结肠癌组织中 BRG1的表达以及与肿瘤病理分级、临床病理分期的相关性。方法选取100例结肠癌组织标本，采用 SP 免疫组化技术，对 BRG1进行染色分析。研究 BRG1与病理分级和临床病理分期的相关性。结果BRG1基因在结肠癌组织中阳性表达率为82．0％。结肠癌组织中 BRG1表达在不同肿瘤病理分级、临床病理分期中差异有统计学意义（χ^2＝23．509，P ＝0．024；χ^2＝25．659，P ＝0．002）；病理分级越高，结肠癌组织中 BRG1表达越强。中晚期结肠癌组织中 BRG1表达较早期明显增强。结论BRG1在结肠癌组织中的表达水平与肿瘤病理分级、临床病理分期密切相关。BRG1在结肠癌的发生、发展中可能发挥重要作用。Objective To study the expression of BRG1 gene in colon cancer and its relationship with histological grade and clinicopathological stages characteristics.Methods The expression of BRG1 -positive cancer cells were detected by immunohistochemistry in 100 cases of colon cancer,and the relationship with histological grade and clinicopathological stages characteristics was analyzed.Results Of the 100 colon cancer specimens analyzed,the positive expression rate was 82.0%.The expression of BRG1 in colon cancer tissue with histological grade and TNM staging was significantly different （χ^2 =23.509,P =0.024;χ^2 =25.659,P =0.002）.The higher the histological grade,the stronger the BRG1 expression in colon cancer tissue.BRG1 expression in advanced colon cancer tissue was significantly enhanced in the early stage.Conclusion The appearance of BRG1 -positive cancer cells is associated with histological grade and clinicopathological stages characteristics.BRG1 might play an important role in the development of colon cancer.

关 键 词：结肠肿瘤 基因 BRG1 病理学 临床 

分 类 号：R735.35[医药卫生—肿瘤]