早期乳腺癌患者保乳术后体外部分乳腺加速照射的循证治疗  

Evidence-Based Treatment for Early-Stage Breast Cancer Patients after Breast-Conserving Surgery Treated with External Beam Accelerated Partial-Breast Irradiation

作　　者：郑建清[1] 黄碧芬 刘静静[1] 陈明芬[1] 苏菁菁[1] 蔡群榕[1] 白志刚[1] 

机构地区：[1]福建医科大学附属第二医院,福建泉州362000 [2]泉州医学高等专科学校附属人民医院,福建泉州362000

出　　处：《循证医学》2017年第1期59-64,共6页The Journal of Evidence-Based Medicine

基　　金：福建医科大学附属第二医院苗圃基金资助项目(2013MP16)

摘　　要：目的应用循证医学方法为1例行保乳术后的早期乳腺癌患者确定放疗方案。方法计算机检索Pub Med、Cochrane图书馆、CNKI、Wanfang和VIP数据库,纳入所有关于乳腺癌外照射部分乳腺加速放疗的随机对照试验,放疗技术不限。检索时限均为从建库至2015年10月31日。结果检索到3项随机对照试验。与全乳腺放疗相比,外照射加速部分乳腺放疗能够显著缩短放疗时间、不增加局部复发的风险,但提高美容效果、延长生存时间的作用有限。结论外照射加速部分乳腺放疗实现部分早期乳腺癌术后辅助放疗是可行的,但其疗效与远期生存结果仍需随机对照试验进一步研究。Objective To determine the radiotherapy scheme for an early-stage breast cancer patients after breastconserving surgery based on evidence- based medicine. Methods We searched databases including Pub Med,The Cochrane Library,CNKI,Wanfang Database and VIP Database up to October 31,2015,to collect relevant randomized controlled trials（RCTs）about external beam accelerated partial-breast irradiation for early-stage breast cancer patients with breast-conserving surgery. Radiotherapy techniques were not limiting conditions. Results 3 RCTs were retrieved.Compared with whole breast irradiation,external beam accelerated partial-breast irradiation can significantly shorten the treatment time of radiotherapy and does not increase the risk of local recurrence,while it is limited to improve cosmetic results and to prolong the survival time. Conclusions Adjuvant radiotherapy with external beam accelerated partial-breast irradiation is feasible for some early-stage breast-cancer with breast-conserving surgery,while additional RCTs are needed to assess the long-term efficacy,survival results and toxicity of this approach.

关 键 词：乳腺癌 加速部分乳腺照射 适形放射治疗 保乳术 

分 类 号：R737.9[医药卫生—肿瘤]