A Review of the Functional and Anatomical Default Mode Network in Schizophrenia  

作　　者：Mao-Lin Hu Xiao-Fen Zong J. John Mann Jun-Jie Zheng Yan-Hui Liao Zong-Chang Li Ying He Xiao-Gang Chen Jin-Song Tang 

机构地区：[1]Department of Psychiatry, The Second Xiangya Hospital,Central South University, Changsha 410011, China [2]Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute and Departments of Psychiatry and Radiology, Columbia University, New York,NY 10032, USA [3]Mental Health Institute of Central South University, China National Clinical Research Center on Mental Disorders(Xiangya), China National Technology Institute on Mental Disorders, Hunan Technology Institute of Psychiatry, Hunan Key Laboratory of Psychiatry and Mental Health, The Second Xiangya Hospital of Central South University, Changsha 410011, China [4]Key Laboratory for Neurolnformation of the Ministry of Education, School of Life Science and Technology and Center for Information in BioMedicine, University of Electronic Science and Technology of China,Chengdu 611731, China [5]Department of Psychiatry and Biobehavioral Sciences,UCLA Semel Institute for Neuroscience, David Geffen School of Medicine, Los Angeles, CA 90024, USA

出　　处：《Neuroscience Bulletin》2017年第1期73-84,共12页神经科学通报（英文版）

基　　金：supported by the National Natural Science Foundation of China(81271484,81471361,30900486,and 81371480);the National Basic Research Development Program(973 Program)of China(2012CB517904);the Nation Sponsored Study Abroad Program from China Scholarship Council(201506370095)

摘　　要：Schizophrenia is a severe mental disorder characterized by impaired perception, delusions, thought disorder, abnormal emotion regulation, altered motor function, and impaired drive. The default mode network （DMN）, since it was first proposed in 2001, has become a central research theme in neuropsychiatric disorders, including schizophrenia. In this review, first we define the DMN and describe its functional activity, functional and anatomical connectivity, heritability, and inverse correlation with the task positive network. Second, we review empirical studies of the anatomical and functional DMN, and anti-correlation between DMN and the task positive network in schizophrenia. Finally, we review preliminary evidence about the relationship between antipsychotic medications and regulation of the DMN, review the role of DMN as a treatment biomarker for this disease, and consider the DMN effects of individualized therapies for schizophrenia.Schizophrenia is a severe mental disorder characterized by impaired perception, delusions, thought disorder, abnormal emotion regulation, altered motor function, and impaired drive. The default mode network （DMN）, since it was first proposed in 2001, has become a central research theme in neuropsychiatric disorders, including schizophrenia. In this review, first we define the DMN and describe its functional activity, functional and anatomical connectivity, heritability, and inverse correlation with the task positive network. Second, we review empirical studies of the anatomical and functional DMN, and anti-correlation between DMN and the task positive network in schizophrenia. Finally, we review preliminary evidence about the relationship between antipsychotic medications and regulation of the DMN, review the role of DMN as a treatment biomarker for this disease, and consider the DMN effects of individualized therapies for schizophrenia.

关 键 词：SCHIZOPHRENIA Default mode network Task-negative network Task-positive network ANTIPSYCHOTICS Resting state . fMRI DTI 

分 类 号：R749.3[医药卫生—神经病学与精神病学]