A New Link Between Insulin Signaling and Fragile X Syndrome  

作　　者：Bei Bu Luoying Zhang 

机构地区：[1]Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology,Huazhong University of Science and Technology,Wuhan 430074, China [2]Collaborative Innovation Center for Brain Science,Huazhong University of Science and Technology,Wuhan 430074, China

出　　处：《Neuroscience Bulletin》2017年第1期118-120,共3页神经科学通报（英文版）

基　　金：supported by grants from the National Natural Science Foundation of China(31471125 and 31671215);the‘‘One Thousand Talents Plan of China’’

摘　　要：Fragile X syndrome （FXS） is the most common cause of inherited intellectual disability and the most common known genetic cause of autism or autism spectrum disorders. FXS is caused by silencing or mutation of the fragile X mental retardation gene （FMR1）, a known RNA-binding protein that acts as a negative regulator of translation [1, 2]. FXS patients demonstrate a myriad of symptoms that can vary widely between individuals, including impaired cognition, physical abnormalities, sleep problems, hyperarousal to sensory stimuli, increased anxiety, obsessive compulsive disorder-like behavior, attention-deficit hyperactive disorder symptoms, self-injurious behavior, aggression, and increased risk of seizures [3]. The molecular mechanisms underlying FXS are not clear, and currently there is no ideal treatment.Fragile X syndrome （FXS） is the most common cause of inherited intellectual disability and the most common known genetic cause of autism or autism spectrum disorders. FXS is caused by silencing or mutation of the fragile X mental retardation gene （FMR1）, a known RNA-binding protein that acts as a negative regulator of translation [1, 2]. FXS patients demonstrate a myriad of symptoms that can vary widely between individuals, including impaired cognition, physical abnormalities, sleep problems, hyperarousal to sensory stimuli, increased anxiety, obsessive compulsive disorder-like behavior, attention-deficit hyperactive disorder symptoms, self-injurious behavior, aggression, and increased risk of seizures [3]. The molecular mechanisms underlying FXS are not clear, and currently there is no ideal treatment.

关 键 词：FXS A New Link Between Insulin Signaling and Fragile X Syndrome FMR 

分 类 号：R749[医药卫生—神经病学与精神病学]