精神分裂症患者血清甲状腺激素的研究  

Study of serum thyroid hormones in patients with schizophrenia

作　　者：游青青[1] 杨宇[1] 陈广阳[1] 曾海深[1] 

机构地区：[1]佛山市第三人民医院,广东佛山528041

出　　处：《医学检验与临床》2017年第1期13-15,9,共4页Medical Laboratory Science and Clinics

摘　　要：目的：探讨精神分裂症患者血清甲状腺激素水平的变化。方法：采用阳性和阴性症状量表（PANSS）法，评定60例阳性症状精神分裂症患者和60例阴性症状精神分裂症患者住院病人，60例正常人对照组。分别在治疗前检测血清甲状腺激素：三碘甲状腺原氨酸（T3）、四碘甲状腺原氨酸（T4）、促甲状腺素（TSH）、游离三碘甲状腺原氨酸（FT3）、游离甲状腺素（FT4）。结果：阳性症状精神分裂症组与正常对照组比较：FT4（17.885±6.061,14.859±2.270）经检验=3.622（P〈0.01）差异有非常显著性。FT3（4.998±1.129,4.657±0.541）、T4（122.423±32.524,111.268±24.024）、T3（2.053±1.425,1.635±0.275），值分别为2.112，2.137，2.230（均P〈0.05）差异均有显著性。TSH （3.77±0.73，4.03±1.67）（P〉0.05）差异无显著性。阴性症状精神分裂症患者组与正常对照组比较：FT4（15.926±2.345,14.859±2.270）经检验=2.531（P〈0.05）差异有显著性，FT3、T4、T3、TSH和TSH均（P〉0.05）差异无显著性。结论：精神分裂症患者病情与血清甲状腺激素水平有关。阳性症状患者甲状腺激素浓度升高明显。Objective： To investigate the changes of serum thyroid hormone levels in patients with schizophrenia. Methods：Using positive and negative symptom scale （ PANSS） method, 60 schizophrenic patients with positive symptoms and 60 with negative symptoms were assessed. At the same time, 60 cases of normal hospitalized patients were included as control group. Detection of serum thyroid hormone respectively before treatment, including three triiodothyronine （ T3） , four triiodothyronine （T4） , thyroid stimulating hormone （TSH） , free three triiodothyronine （FT3） , free thyroxine （FT4） . Results： The positive symptoms of schizophrenia group were compared with the normal group： FT4 （ 17.885 ±6.061, 14.859 ±2.270） by test =3.622 （ P〈0.01） , with significant difference; FT3 （4.998±1.129,4.657±0.54） , T4 （122.423±32.524, 111.268±24.024） ; T3 （2.053± 1.425, 1.635±0.275） , values were respectively 2.112, 2.137, 2.230, significantly different （ P〈0.05） ; TSH （3.77±0.73, 4.03± 1.67） , without significance （ P〉0.05） . Negative symptoms of schizophrenia patients group were compared with the normal control group. There was significant difference in FT4 （15.926±2.345, 14.859±2.270） by test for =2.531 （ P〈0.05） in the patients with negative symptoms of schizophrenia. No other significance were found in FT3, T4, T3 and TSH. Conclusion： The level of serum thyroid hormone is related to the condition of the patient with schizophrenia. The concentration of thyroid hormone was significantly increased in patients with positive symptoms.

关 键 词：精神分裂症 甲状腺激素 甲状腺激素(PANSS)量表 

分 类 号：R749.3[医药卫生—神经病学与精神病学]