小儿急性白血病化疗治疗并发口腔溃疡的影响因素分析  

Analysis of the factors influencing the occurrence of oral ulcer during the treatment of acute leukemia in child patients

作　　者：赵芸[1] 郭妍妍[1] 张春霞[1] 张称心[1] 毕小朵[1] 

机构地区：[1]内蒙古医科大学附属医院儿科,呼和浩特0100500

出　　处：《癌症进展》2017年第1期97-99,共3页Oncology Progress

摘　　要：目的探讨小儿急性白血病化疗治疗并发口腔溃疡的影响因素。方法收集急性白血病患儿82例,分析化疗后发生口腔溃疡的情况,并对其发生口腔溃疡的危险因素进行多因素Logistic回归分析。结果口腔溃疡发生率为17.1%(14/82);年龄(OR=6.068,95%CI:2.057~17.903)、化疗时间(OR=3.728,95%CI:1.234~11.263)、抗生素使用时间(OR=2.646,95%CI:1.106~6.330)、住院时间(OR=4.339,95%CI:1.775~10.607)、体重(OR=2.593,95%CI:1.456~4.618)是口腔溃疡发生的独立危险因素(P﹤0.05)。结论小儿急性白血病化疗治疗过程中口腔溃疡的发生与患儿的年龄、化疗时间、抗生素使用时间、住院时间、体重有关,临床治疗过程中需引起重视,做好干预工作。Objective To investigate the factors influencing the occurrence of oral ulcer in children with acute leuke-mia during the treatment. Method 82 children with acute leukemia were analyzed for the incidence of oral ulcer after chemotherapy, and multivariate Logistic regression analysis was performed to evaluate the risk factors. Result The inci-dence rate of oral ulcer was 17.1% （14/82）; Age （OR=6.068, 95% CI： 2.057-17.903）, duration of chemotherapy （OR=3.728, 95%CI：1.234-11.263）, time of antibiotics use （OR=2.646, 95%CI：1.106-6.330）, hospital stay （OR=4.339, 95%CI：1.775-10.607）, weight （OR=2.593, 95%CI：1.456-4.618） were independent prognostic factors for oral ulcer （P〈0.05）. Conclusion The occurrence of oral ulcer during chemotherapy in children with acute leukemia is associated with age, duration of chemotherapy, time of antibiotics use, hospital stay and weight, thus clinical interventions are required.

关 键 词：小儿白血病 化疗 口腔溃疡 

分 类 号：R733.71[医药卫生—肿瘤]