HPV检测在农村宫颈癌筛查中的作用  

The Role of HPV in Prevention Screening of Cervical Cancer in Rural Area

作　　者：朱博[1] 王维琴[2] 吴彬[2] 姜国华 肖伟[1] 刘运泳[1] 于慧会[1] 毕雪[1] 陈肖扬 邢晓静[1] 王丹波[1] 朴浩哲[1] 

机构地区：[1]中国医科大学肿瘤医院/辽宁省肿瘤医院,辽宁省肿瘤防治办公室,辽宁沈阳110004 [2]沈阳市苏家屯区妇婴医院,辽宁沈阳110100 [3]沈阳市苏家屯区第一医院,辽宁沈阳110100 [4]沈阳医学院,辽宁沈阳110004

出　　处：《中国肿瘤》2017年第3期170-174,共5页China Cancer

基　　金：辽宁省临床能力建设项目(LNCC-H04-2015)

摘　　要：[目的]了解HPV检测在辽宁省沈阳市苏家屯地区农村妇女宫颈癌筛查过程中的作用,为宫颈癌筛查提供科学依据。[方法]对2014~2015年间自愿接受宫颈癌筛查的35~64岁农村常住妇女,进行调查、取样和HPV检测。[结果]对10 000名35~64岁妇女进行宫颈癌筛查,发现宫颈癌癌前病变80人(其中CIN1为36人,CIN2为30人,CIN3为14人),宫颈癌3人。高危型HPV阳性共1209人,高危型HPV阳性感染率随年龄的升高而升高。HPV的感染率随着病变程度加重而升高;宫颈上皮内瘤变和宫颈癌组HPV 16型的比例显著性高于其他组。[结论]HPV检测在宫颈癌的筛查过程中对提高早诊率具有重要的意义。[Purpose] To investigate the role of HPV in cervical cancer screening in rural areas of Sujiatun,Shenyang city,Liaoning province,and to provide scientific basis for the prevention screening of cervical cancer. [Methods] From 2014 to 2015,rural women aged 35~64 volunteered for the screening of cervical cancer were investigated,sampled and performed HPV detection test.[Results] After the screening for cervical cancer in 10000 rural women,cervical precancerous lesions were found in 80 cases（CIN1 36 cases,CIN2 30 cases,CIN3 14 cases）,and 3 cases with cervical cancer. There were 1209 cases with positive HPV,and the HPV positive rate increased by age increasing. The HPV infection rate increased with the severity of cervical cancer. HPV 16 positive rate in cervical precancerous lesions and cervical cancer group was significantly higher than that in other cervix lessions. [Conclusion] The HPV detection in the screening of cervical cancer have an important significance to increase the early diagnosis rate and improve health con-dition. The screening of cervical cancer in rural areas is necessary and feasible.

关 键 词：宫颈病变 人乳头状瘤病毒 筛查 早诊早治 

分 类 号：R737.33[医药卫生—肿瘤]