DcR3蛋白在人食管鳞状细胞癌中的表达及临床意义  

Expression and Clinical Significance of DcR3 Protein in Oesophageal Squamous Cell Carcinoma

作　　者：胡尕伟 李庆新[1] 黄亚琼[2] 伍治强[1] 王占鹏[1] 

机构地区：[1]兰州军区兰州总医院胸外科,甘肃兰州730050 [2]兰州军区兰州总医院乳腺科,甘肃兰州730050

出　　处：《现代生物医学进展》2017年第1期104-107,共4页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(81202085)

摘　　要：目的:探讨诱骗受体(Decoy receptor 3,Dc R3)蛋白在人食管鳞状细胞癌中的表达和临床意义。方法:通过免疫组化的方法,在人食管鳞状细胞癌组织和正常食管粘膜组织各112例中检测Dc R3蛋白的表达差异,并分析Dc R3蛋白表达与食管鳞状细胞癌临床病理学特征间的相关性。结果:在组织标本中检测发现,Dc R3蛋白在食管鳞状细胞癌组织中的阳性表达为72.3%,在正常食管粘膜组织中的阳性表达为25.9%。卡方检验分析表明,Dc R3蛋白在食管鳞状细胞癌组织中的阳性表达与食管鳞状细胞癌的临床分级(P=0.002)、淋巴结转移(P<0.001)、组织学分级(P=0.01)具有显著相关性,而与患者的年龄(P=0.673)、性别(P=0.378)、抽烟史(P=0.392)、饮酒史(P=0.093)等均无关。Spearman相关性分析检测发现,Dc R3蛋白高表达与高临床分级(r=-0.213,P=0.024)、高组织学分级(r=-0.285,P=0.002)、淋巴结转移(r=-0.568,<0.001)呈正相关,而与食管鳞状细胞癌患者的年龄、性别、吸烟史、饮酒史等均无相关性(P>0.05)。结论:Dc R3蛋白在食管鳞状细胞癌组织中表达更高,且与食管鳞状细胞癌疾病的进展、转移呈正相关。Dc R3蛋白表达可用来检测食管鳞状细胞癌疾病严重程度。Objective： To investigate the expression and clinical significance of DcR3（Decoy receptor 3） protein in human oesophageal squamous cell carcinoma. Methods： Expression status of DcR3 was detected by immunohistochemistry in 112 cases of normal esophageal tissues and oesophageal squamous cell carcinoma tissues. Expressions, correlations and clinical significance of DcR3 protein were also analyzed. Results： In oesophageal squamous cell carcinoma tissues, the positive expression of DcR3 protein was 72.3% and in normal esophageal tissues the postive expression of DcR3 protein was 25.9%. The chi square test suggested that DcR3 protein expression was correlated with clinical stage（P=0.002）, lymph node metastasis（P〈0.001）, histological differentiation（P=0.01）, but was not correlated with age（P=0.673）, gender（P=0.378）, cigarette smoking（P=0.392）, alcohol drinking（P=0.093）. Correlation analysis suggested that DcR3 expressions were positively correlated with clinical stage（r=-0.213, P=0.024）, lymph node metastasis（r=-0.568, 0.001）, histological differentiation（r=-0.285, P=0.002）. However, DcR3 expressions were not positively correlated with age, gender, cigarette smoking,alcohol drinking（P〈0.093）. Conclusion： In oesophageal squamous cell carcinoma, expressions of DcR3 protein were overexpressed and positively correlated with tumor progression and invasion. DcR3 protein expression may serve as a candidate prognostic biomarker in oesophageal squamous cell carcinoma progression.

关 键 词：食管鳞状细胞癌 DCR3 免疫组化 临床意义 

分 类 号：R735.1[医药卫生—肿瘤]