不可逆电穿孔消融治疗肝恶性肿瘤现状  

Irreversible electroporation ablation for the treatment of malignant tumors of liver: present clinical situation

作　　者：秦子淋 曾健滢[1,2] 牛立志[1,2] 

机构地区：[1]暨南大学医学院,广州510632 [2]暨南大学医学院附属复大肿瘤医院(广州复大肿瘤医院)

出　　处：《介入放射学杂志》2017年第3期285-289,共5页Journal of Interventional Radiology

摘　　要：肝恶性肿瘤发病率逐年增加。中国肝癌发病率为25.7/10万。然而,对侵犯或毗邻肝门重要脏器的肝恶性肿瘤,难以手术切除且化放疗疗效不佳。近年来,不可逆电穿孔(IRE)消融技术逐渐兴起,作为一种新的非热能形式的消融方法,其通过产生短时高压的电脉冲在细胞膜上产生纳米级的不可逆损伤。国内外研究指出,该技术在治疗不可手术切除的原发性或转移性肝肿瘤时,可有效灭活肿瘤组织并保留管腔架构,不会损伤大血管或胆管等。本文对IRE的设备构成、作用机制、临床前研究、临床应用方法以及临床疗效进行综述,以期为该技术在临床得以推广应用提供参考。The incidence of liver cancer has been increasing year by year. In China, the incidence of liver cancer is 25.7/10 million. However, when the important organs have been involved or when the malignant liver tumors are located adjacent to the hepatic portal vital organs, the lesions are usually difficult to be surgically removed, and the curative results of chemotherapy and radiotherapy for such lesions are often poor. In recent years, along with the gradual rise of ablation techniques, the irreversible electroporation （IRE）, regarded as a new ablation method that uses non-thermal energy, has been widely employed in clinical practice. Through generating instantaneous high voltage electrical pulses, IRE produces irreversible nanoscale damage to the cell membrane. Both domestic and foreign researches have indicated that for the treatment of inoperable primary or metastatic liver tumors IRE can effectively inactivate the tumor tissue while the lumen architecture of the vessels can be preserved and large vessel or bile duct will not be damaged. This paper aims to make a comprehensive review about IRE device structure, mechanism of therapeutic action, preclinical studies, clinical application methods and clinical efficacy in order to provide reference for the application of this technology in clinical practice.

关 键 词：不可逆电穿孔 肝癌 消融 

分 类 号：R735.7[医药卫生—肿瘤]