慢性便秘与结直肠肿瘤的相关性  

Correlation between chronic constipation and colorectal neoplasms

作　　者：刘宝华[1] 

机构地区：[1]第三军医大学大坪医院野战外科研究所普通外科全军便秘诊治中心,重庆400042

出　　处：《中华胃肠外科杂志》2017年第3期255-257,共3页Chinese Journal of Gastrointestinal Surgery

基　　金：重庆市国际合作计划项目（CSTC201110010）;国家自然科学基金（81100259）;重庆市自然科学基金（CSTC2011jjA10061）

摘　　要：慢性便秘与结直肠肿瘤的相关性一直是人们关注的问题，长期以来陆续有国内外流行病学及临床研究就此问题进行探讨和分析。通过结合国内外文献，从便秘与结直肠息肉、便秘与结直肠癌以及结肠黑变病（MC）和泻剂与结直肠肿瘤关系这3个方面进行便秘与结直肠肿瘤的相关性探讨，发现便秘能够显著增加结直肠息肉的发病率，尽管便秘不显著增加结直肠癌的发病率，但却是发生结直肠癌的危险因素；另外，MC和泻剂与结直肠息肉的发生率也密切相关。由于结直肠息肉是癌前病变，所以，对于长期便秘患者应该尽量少用蒽醌类泻剂，对结直肠息肉患者定期随访是必要的。The correlation between chronic constipation and colorectal neoplasms has been arousing wide interest. There have been a number of domestic and international epidemiological and clinical researches focusing on this issue. Based on these researches, the correlation between constipation and colorectal neoplasms was studied from three aspects： constipation and colorectal polyps; constipation and colorectal cancer; melanosis coli （MC） , laxatives and colorectal neoplasms. We find that constipation can significantly increase the incidence of colorectal polyps and constipation does not significantly increase the incidence of colorectal cancer but is one of the risk factors for colorectal cancer. In addition, MC, laxatives and the incidence of colorectal polyps are also closely correlated. Given the fact that colorectal polyps are precancerous lesions, patients with long-term constipation should take less anthraquinone laxatives, and those with colorectal polyps should be followed up periodically.

关 键 词：便秘 结直肠肿瘤 相关性 

分 类 号：R574.62[医药卫生—消化系统] R735.34[医药卫生—内科学]