脐血干细胞移植治疗慢性肝衰竭患者的临床观察  

Clinical study of the umbilical blood stem cells transplantation in the treatment of chronic liver failure

作　　者：张岁[1] 郭力红[1] 杨大伟[1] 柳立平[1] 贾蓓[1] 马文波[1] 王海舫[1] ZHANG Sui GUO Lihong YANG Dawei LIU Liping JIA Bei MA Wenbo WANG Haifang(Live Disease Diagnoses and Treatment Center of Chinese Western Medicine, the First Hospital of Hebei Medical University, Shijiazhuang 050031, China)

机构地区：[1]河北医科大学第一医院中西医结合肝病诊疗中心,石家庄市050031

出　　处：《实用医学杂志》2017年第4期565-568,共4页The Journal of Practical Medicine

基　　金：河北省医学科学研究重点课题(编号:20150636)

摘　　要：目的:观察脐血干细胞移植治疗慢性肝衰竭患者的安全性及临床疗效。方法:慢性肝衰竭患者44例,其中对照组22例,给予内科综合治疗,治疗组22例,在内科综合治疗的基础上给予脐血干细胞治疗。观察治疗前和治疗后2、4、12、24周生化指标、MELD评分、临床症状、生存情况及不良反应。结果:治疗组白蛋白、凝血酶原活动度较对照组升高,MELD评分较对照组降低,生存率较对照组升高,组间比较有统计学差异(P<0.05);两组丙氨酸转氨酶、总胆红素比较无统计学差异(P>0.05)。治疗4周后,治疗组乏力、食欲、腹胀及腹水情况均较对照组改善,差异有统计学意义(P<0.05)。两组患者均未出现明显不良反应,无肝细胞癌发生。结论:脐血干细胞移植治疗慢性肝衰竭患者安全有效,可明显提高患者生存率。Objective To observe the safety and clinic effect of umbilical blood stem cell transplantation for the patients with chronic liver failure （CLF）. Methods 44 patients with CLF were included in the research and divided into two groups, 22 in control group received internal medicine treatment, the other 22 in treatment group received umbilical blood stem cell transplantation in addition to internal medicine treatment. The biochemical index, MELD scores, clinical symptoms, survival situation and adverse reaction of the patients were observed within 2, 4, 12 and 24 weeks. Results Albumin and prothrombin activity of treatment group were higher than those of control group, the MELD scores of the treatment group was lower than that of control group, the survival rate was higher than the control group, and the difference is significant between the two groups （P 〈 0.05）. There was no significant difference between the two groups in terms of alanine aminotransferase and total bilirubin （P 〉 0.05）. After 4 weeks treatment, fatigue, inappetite, abdominal distention and ascitic fluid of the treatment group were better than that of control group, the difference was statistically significant （P 〈 0.05）. Besides, the patients of the both groups did not have any adverse reaction or hepatocellular carcinoma. Conclusion Umbilical blood stem cell transplantation is safe and effective for the patients with CLF and can improve the survival rate of the patients.

关 键 词：慢性肝衰竭 脐血干细胞移植 乙型肝炎病毒 

分 类 号：R575.3[医药卫生—消化系统]