p-MNK1表达水平与非小细胞肺癌术后生存率的关系  

Correlation between p-MNK1 expression and postoperative survival rate in patients with non small cell lung cancer

作　　者：林晓东[1] 吴其年[1] 梁剑菲 顾霞[1] 肖洪广[1] LIN Xiaodong WU qinian LIANG jianfei GU xia XIAO hongguang(The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China)

机构地区：[1]广州医科大学附属第一医院病理科,广州市510120

出　　处：《实用医学杂志》2017年第4期623-626,共4页The Journal of Practical Medicine

基　　金：国家自然科学青年基金资助项目(编号:81201847)

摘　　要：目的:研究p-MNK1在非小细胞肺癌中的表达水平与临床病理特征及预后的关系。方法:应用组织芯片技术、免疫组化技术对115例非小细胞肺癌中p-MNK1表达水平进行分析。结果:p-MNK1在非小细胞肺癌中的表达水平与非小细胞肺癌患者的组织分型(P<0.05)、临床分期(P<0.05)、淋巴结转移(P<0.01)及预后(P<0.05)相关,Cox多重回归分析显示p-MNK1表达量为非小细胞肺癌的独立预后因素之一(P<0.01)。结论:在非小细胞肺癌中,p-MNK1的表达水平与患者预后不良有关,可作为独立预后指标及新的治疗靶点。Objective To investigate the expression of p-MNK 1 in non-small cell lung cancer and its relationship with clinic pathological features and prognosis. Methods The level of p-MNK1 in 115 cases of nonsmall cell lung cancer was detected by tissue microarray technique and immunohistochemistvy technique. Results The level of p-MNK 1 in non-small cell lung cancer was correlated with cancer tissue type （P 〈 0.05）, clinical stage （P 〈 0.05）, lymph node metastasis （P 〈 0.01） and prognosis （P 〈 0.05）. Cox multiple regression analysis showed that p-MNK1 expression was an independent prognostic factor for non-small cell lung cancer （P 〈 0.01）. Conclusion The level of p- MNK1 in nonsmall cell lung cancer is associated with poor prognosis. It can be used as an independent prognostic marker and a new therapeutic target.

关 键 词：非小细胞肺癌 p-MNK1 分子靶点 

分 类 号：R734.2[医药卫生—肿瘤]