Fibroscan在HBV感染者肝纤维化诊断中的临床应用价值探讨  

Investigation on the Clinical Application Value of Fibroscan in the Diagnosis of Liver Fibrosis in Patients with HBV

作　　者：余素琼 覃丽萍[1] 廖咪妮 刘崧[1] 陆秀芳[1] 

机构地区：[1]广东省英德市人民医院,广东英德513000

出　　处：《临床医学工程》2017年第3期291-292,共2页Clinical Medicine & Engineering

基　　金：2015年清远市科技计划项目(项目编号:2015B088)

摘　　要：目的通过对我院初诊为HBV感染患者进行回顾性分析,探讨瞬时弹性成像系统(Fibroscan)在HBV感染者肝纤维化诊断中的临床应用价值。方法选取我院2015年1月至2016年6月收治的HBV感染患者180例,检验其生化指标,对F S和各项生化指标进行多重线性回归分析。结果 (1)根据FS值和血清学检验指标分析的结果,FS值和ALB、TBIL、HA、ALT、LN呈显著相关性(P<0.05)。(2)慢性肝实质损伤组(90例)和肝硬化组(70例)的F S值明显高于急性肝实质损伤组(20例),差异具有统计学意义(P<0.05);肝硬化组的FS值明显高于慢性肝实质损伤组,差异具有统计学意义(P<0.05)。结论通过Fibroscan肝脏瞬时弹性成像仪检测,能够准确地分析出H BV感染者肝纤维化程度及相关肝硬度值,可用于指导临床医师及时识别肝纤维化并进行治疗,预防肝硬化、肝癌的发生。Objective To explore the clinical application value of Fibroscan system in the diagnosis of liver fibrosis in patients with HBV through retrospective analysis on patients who were initially diagnosed as HBV in our hospital. Methods 180 cases of patients with HBV admitted to our hospital from January 2015 to June 2016 were selected. The biochemical indicators of patients were tested to make multiple linear regression analysis towards FS and each biochemical indicator. Results （1）According to FS values and result of serology testing analysis, FS values had significant correlation with ALB, TBIL, HA, ALT and LN （P 〈0.05）. （2）The FS values of chronic liver parenchyma injury group （90 cases） and cirrhosis group （70 cases） were both significantly higher than that of acute liver parenchyma injury group （20 cases）, with statistical differences （P 〈0.05）. The FS value of cirrhosis group was significantly higher than that of chronic liver parenchyma injury group, with statistical difference （P〈0.05）. Conclusions Through Fibroscan imager, liver fibrosis degree and related liver stiffness values of patients with HBV can be accurately analyzed to guide clinician to distinguish and treat liver fibrosis timely, so as to prevent the occurrence of cirrhosis and liver cancer.

关 键 词：瞬时弹性成像系统 HBV感染 肝纤维化 临床诊断 

分 类 号：R575.2[医药卫生—消化系统]