血清转化生长因子-β1水平与短暂性脑缺血发作患者颈动脉粥样硬化的关系  

The correlation between serum transforming growth factor-β1 level and carotid atherosclerosis in TIA patients

作　　者：张坤[1] 曾庆鑫[2] 

机构地区：[1]包头医学院,内蒙古包头014060 [2]内蒙古医科大学第三附属医院神经内科

出　　处：《包头医学院学报》2017年第3期84-86,共3页Journal of Baotou Medical College

基　　金：包头医学院秦文斌科技教育基金(200912)

摘　　要：目的:探讨短暂性脑缺血发作(transient ischemic attack,TIA)患者血清转化生长因子-β1(transforming growth factor-β1,TGF-β1)水平与其颈动脉粥样硬化的关系。方法:随机选取56例TIA患者为TIA组,选择同期健康体检者为对照组;比较两组对象颈动脉内中膜厚度(intima-media thicknesss,IMT),观察颈动脉粥样斑块形成情况并判断斑块性质;采用酶联免疫吸附测定(enzyme linked immunosorbent assay,ELISA)法检测血清TGF-β1水平。结果:TIA组患者颈动脉IMT为(1.21±0.19)mm,高于对照组的(0.91±0.22)mm(P<0.05);TIA组患者的斑块检出率和不稳定斑块检出率均高于对照组(P<0.05);TIA患者中,稳定斑块组患者TGF-β1水平(3175.15±452.09)pg/mL高于不稳定斑块组(2845.61±445.91)pg/mL(P<0.05)。结论:检测血清TGF-β1水平,对于了解TIA患者颈动脉粥样斑块的稳定性、判断TIA的预后具有一定的临床意义。Objective：To detect the correlation between serum level of transforming growth factor - β1 （TGF - β1 ） and carotid atheroselerosis in patients with transient ischemic attack （TIA）. Metho4s：56 TIA patients were selected as the TIA group, and 50 healthy subjects were collected as the control group; the intima - media thicknesss （IMT） and the atberosclerotic plaques feature were examined using color ultrasound technique; the serum levels of TGF - β1 were detected by enzyme linked immunosorbent assay （ELISA）. Remits：The IMT of TIA patients was （ 1.21 ± 0.19） ram, which was higher than that in controls （0.91 ± 0.22） mm （ P 〈 0.05）. Compared with the controls, the percentage of plaques and the percentage of unstable plaques in TIA patients were both increased （ P 〈0.05） ; In TIA patients, the serum TGF -β1 in patients with stable plaques was （3 175.15 ±452.09）pg/mL, which was higher than that in the patients with unstable plagues （2 845.61 ± 445.91 ） pg/mL（ P 〈 0.05）. Conelmion：Detection of serum TGF-β1 has a certain clinical significance in understanding the stability of carotid ar- tery atheromatous plaque and estimating the prognosis of TIA patients. KEY WORI）8 Transforming growth factor -β1 ;Transient ischemic attack; Carutid atheroselerosis

关 键 词：转化生子因子β1 短暂性脑缺血发作 颈动脉粥样硬化 

分 类 号：R743.31[医药卫生—神经病学与精神病学]