血管性认知功能障碍磁共振波谱成像研究  

Study of the magnetic resonance spectroscopy in patients with vascular cognitive impairment

作　　者：陆强彬[1] 张慧萍[1] 朱祖福[1] 柏燕燕[1] 杨江胜[1] 

机构地区：[1]江苏省江阴市人民医院神经内科,214400

出　　处：《蚌埠医学院学报》2016年第12期1673-1675,共3页Journal of Bengbu Medical College

摘　　要：目的：利用磁共振波谱（MRS）技术研究血管性认知功能障碍（VCI）患者颅内代谢物的变化特征。方法：对26例非痴呆型血管性认知障碍（VCIND）患者、20例血管性痴呆（Va D）患者及20名正常对照组,应用MRS测定3组间左侧扣带回后部、左侧背侧丘脑、左侧额叶白质区及左侧海马区的N-乙酰天冬氨酸（NAA）、胆碱（Cho）、肌酸（Cr）值及NAA/Cr、Cho/Cr,比较3组间的差异。结果：与对照组比较,VCIND组左侧扣带回后部、左侧额叶白质区和左侧海马NAA/Cr均减低（P〈0.05~P〈0.01）;Va D组左侧扣带回后部、左侧背侧丘脑和左侧海马NAA含量均较对照组减低（P〈0.05~P〈0.01）,左侧扣带回后部、左侧额叶白质区和左侧海马NAA/Cr比值较对照组减低（P〈0.01）;3组不同部位Cho及Cho/Cr比值差异无统计学意义（P〉0.05）。与VCIND组比较,Va D组左侧扣带回后部NAA/Cr,左侧海马NAA、NAA/Cr减低（P〈0.05~P〈0.01）。结论：VCIND与Va D患者颅内多个脑区代谢物存在差异,以NAA及NAA/Cr变化为主。Objective： To investigate the characteristics of brain metabolites in patients with vascular cognitive impairment（ VCI）using magnetic resonance spectroscopy（ MRS）. Methods： Twenty-six patients with vascular cognitive impairment no dementia（ VCIND group）,20 patients with vascular dementia（ Va D group） and 20 normal people（ control group） were investigated. The levels of the N-acetyl aspartate（ NAA）,choline（ Cho）,creatine（ Cr）,and the metabolite ratios of NAA / Cr and Cho / Cr in left rear of the cingulate gyrus,left dorsal thalamus,left frontal white matter（ FLWM） and left hippocampus in three groups were measured and compared.Results： Compared with the control group,the metabolite ratio of NAA / Cr in left rear of the cingulate gyrus,left frontal white matter and left hippocampus decreased in VCIND patients（ P〈0. 05 to P〈0. 01）,the level of NAA in left rear of the cingulate gyrus,left dorsal thalamus and left hippocampus decreased in Va D patients（ P〈0. 05 to P〈0. 01）,and the metabolite ratio of NAA / Cr in left rear of the cingulate gyrus,left frontal white matter and left hippocampus decreased in Va D group（ P〈0. 01）. The differences of the level of Cho and Cho / Cr in different areas between 3 groups were not statistically significant（ P〈0. 05）. Compared with the VCIND group,the metabolite ratio of NAA / Cr in left rear of the cingulate gyrus,the level of NAA and metabolite ratio of NAA / Cr in left hippocampus decreased in Va D group（ P〈0. 05 to P〈0. 01）. Conclusions： The metabolite differences in different brain regions exist in VCIND and Va D patients,especially for changes of the level of NAA and the ratio of NAA / Cr.

关 键 词：血管性认知功能障碍 血管性痴呆 磁共振波谱 代谢物 

分 类 号：R749.16[医药卫生—神经病学与精神病学]