急性脑梗死患者同型半胱氨酸与颈动脉斑块的相关分析  

Correlation between homocysteine and carotid plaque in patients with acute cerebral infarction

作　　者：孙明[1] 刘芹芹[1] 吴超[1] 陆永姝 

机构地区：[1]南京鼓楼医院集团宿迁市人民医院,江苏宿迁223800

出　　处：《临床医药文献电子杂志》2016年第48期9483-9484,共2页Electronic Journal of Clinical Medical Literature

摘　　要：目的分析急性脑梗死患者同型半胱氨酸与颈动脉斑块的相关性。方法选取2015年6月-2016年6月我院急性脑梗死患者100例为研究对象，将有斑块的患者分为研究组，无斑块患者分为常规组，各50例。使用彩色多普勒超声检测患者颈动脉粥样硬化斑块的有无，以及斑块厚度、膜厚度。发病3d内测量血清HCY水平。结果研究组HCY中位数为12．5μmol／L，常规组HCY中位数为15．6μmol／L，Spearman检验表明颈动脉斑块最大厚度与HCY关系为正相关，差异有统计学意义（r=0.235，P〈0.05）。回顾性分析Logistic表明，患者年龄、高血压病史、男性性别是影响斑块形成的主要原因，而HCY与斑块形成无关系，HCY与颈动脉斑块最大厚度关系为正相关。结论研究组患者HCY明显高于常规组，HCY与颈脉动斑块最大厚度关系。呈正相关。Objective To analyze the relationship between homocysteine and carotid plaque in patients with acute cerebral infarction. Methods Randomly selected in June 2015 to 2016 June in our hospital in patients with acute cerebral infarction in 100 cases, as the research object, there is a plaque of patients divided into study group and non plaque were divided into routine group, 50 cases in each group, using color Doppler ultrasonic detection in patients with carotid atherosclerotic plaque of, and plaque thickness and film thickness. Measurement of serum HCY levels in patients with onset of 3D. Results the median HCY in the study group was 12.5, the median HCY was 15.6, and the rank sum test was P=0.012. Spearman test showed that the maximum thickness of carotid artery plaque was positively correlated with HCY, and the coefficient was r=0.235, P〈0.05. Retrospective logistic analysis showed that patient age, history of hypertension, male gender is the main reason for the formation of plaque, and Hcy and plaque formation without relationship, relationship between Hcy and carotid artery plaque maximum thickness is positive correlation. Conclusion HCY in the study group was significantly higher than that in the conventional group, HCY was positively correlated with the maximum thickness of the carotid pulse.

关 键 词：颈动脉斑块 脑梗死 多普勒超声 同型半胱氨酸 

分 类 号：R743.3[医药卫生—神经病学与精神病学]