慢阻肺患者血清炎性指标、血浆及尿液游离氨基酸的变化研究  

Changes of serum inflammatory indicators,plasma and urine free amino acid of patients with chronic obstructive pulmonary disease

作　　者：陈嵩[1,2] 任涛[1] 万健[2] 顾文超[3] 邓国平[3] 

机构地区：[1]同济大学附属东方医院呼吸内科,上海200120 [2]上海市浦东新区人民医院急诊与危重病科,上海201299 [3]上海市浦东新区人民医院呼吸内科,上海201999

出　　处：《实用临床医药杂志》2017年第3期22-24,共3页Journal of Clinical Medicine in Practice

基　　金：上海市卫生局基金(281223)

摘　　要：目的研究慢阻肺患者血清炎性指标、血浆及尿液游离氨基酸的变化。方法将2014年6月—2016年4月期间本院收治的62例慢阻肺患者设为观察组,并选取同时间段于本院进行体检的62名健康人员为对照组,比较2组血清炎性指标、血浆及尿液游离氨基酸,并比较观察组中不同GOLD分级与处于不同分期时的血清炎性指标、血浆及尿液游离氨基酸指标。结果观察组血清炎性指标均高于对照组,血浆游离氨基酸指标均低于对照组,且观察组中不同GOLD分级与处于不同分期患者的血清炎性指标、血浆游离氨基酸指标也存在显著差异(P<0.05),但2组的尿液游离氨基酸指标无显著差异(P>0.05)。结论慢阻肺患者血清炎性指标及血浆游离氨基酸的变化显著,慢阻肺严重程度及疾病分期对其表达影响较大,但尿液游离氨基酸则无显著波动,因此血清炎性指标与血浆游离氨基酸对慢阻肺患者的检测价值较高。Objective To study changes of serum inflammatory indicators, plasma and urine free amino acid of patients with chronic obstructive pulmonary disease. Methods A total of 62 patients with chronic obstructive pulmonary disease in our hospital from June 2014 to April 2016 were selected as observation group, 62 healthy with physical examination in our hospital during the same time were selected as control group, the serum inflammatory indicators, plasma and urine free amino acid of two groups were compared, and the above indicators of observation group with different GOLD classifications and stages were compared too. Results The serum inflammatory indicators of observation group were all higher, and plasma free amino acid indicators were all lower than that of control group, and the seruminflammatory indicators and plasma free amino acid indicators of observation group with different GOLD classifications and stages showed significant differences （ P 〈 0.05 ） , while the urine free amino acid indicators of two groups had no significant differences（ P 〉0.05 ）. Conclusion The change of serum inflammatory indicators and plasma free amino acid of patients with chronic obstructive pulmonary disease are obvious, and the influence of severity degree and disease stages for the expression are greater , while the urine free amino acid have no obvious fluctuation , so the detection value of serum inflammatory indicators and plasma free amino acid of patients with chronic obstructive pulmonary disease are higher.

关 键 词：慢阻肺 血清 炎性指标 游离氨基酸 

分 类 号：R441.8[医药卫生—诊断学]