胃肠缺血缺氧应激损伤修复的新策略:细胞因子联合基因治疗  

Cytokine gene therapy for treatment of ischemia and hypoxia stress induced gastrointestinal injury

作　　者：哈小琴[1] Xiao-Qin Ha(Clinical Laboratory, Lanzhou General Hospital of Lanzhou Military Area Command, Lanzhou 730050, Gansu Province, Chin)

机构地区：[1]兰州军区兰州总医院检验中心,甘肃省兰州市730050

出　　处：《世界华人消化杂志》2017年第6期479-483,共5页World Chinese Journal of Digestology

摘　　要：应激引发的胃肠缺血缺氧损伤是一种常见的消化系统疾病,应激导致胃肠损伤的机制复杂,临床上治疗手段多样,但治疗效果并不理想.随着人们对细胞因子研究的不断深入,许多与胃肠缺血缺氧损伤关系密切的细胞因子如肝细胞生长因子、低氧诱导因子及角质细胞生长因子等已被大量的研究,有关细胞因子介入疾病治疗的研究也越来越多,研究者将细胞因子构建到真核表达载体上制备成基因治疗药物,通过口服给损伤局部组织中转移细胞因子基因达到治疗目的.细胞因子联合基因治疗可能是一种安全、有效的胃肠缺血缺氧应激损伤修复的新策略,这将会为缺氧缺血性疾病的机制及治疗提供新的观点和方法,本文将对相关内容展开详细论述.Stress induced gastrointestinal ischemia and hypoxia injury is a common digestive system condition caused via complicated mechanisms.Although clinical treatments are diverse,their efficacy is still not satisfactory.Recently,many cytokines have been shown to be related to gastrointestinal ischemia and anoxia,such as hepatocyte growth factor,hypoxia inducible factor,and keratinocyte growth factor.The number of studies on cytokines for the treatment of gastrointestinal diseases is increasing.We have constructed a eukaryotic expression vector carrying cytokine genes to transfer cytokine genes to the local damage tissue to achieve the therapeutic purpose.Cytokine gene therapy may be a safe and effective new strategy for repairing gastrointestinal ischemia and hypoxia stress injury,which will offer a new tool for the mechanism research and treatment of hypoxic ischemic disease.

关 键 词：胃肠 应激损伤 细胞因子 基因治疗 

分 类 号：R57[医药卫生—消化系统]