肠易激综合征与性别相关性激素水平及免疫调节因素的关系  

Relationship of irritable bowel syndrome with sex hormone levels and immunoreguiatory factors

作　　者：罗丹妮[1] 赵妍[1] 陈颖[1] 黄辰[1] 李瑛[1] 周思远[1] Dan-Ni Luo Yan Zhao Ying Chen Chen Huang Ying Li Si-Yuan Zhou(Institute of Acu-moxibustion and Tuina, Chengdu University of TCM, Chengdu 610075, Sichuan Province, China)

机构地区：[1]成都中医药大学针灸推拿学院,四川省成都市610075

出　　处：《世界华人消化杂志》2017年第6期504-508,共5页World Chinese Journal of Digestology

基　　金：国家自然科学基金资助项目;No.81503665;四川省教育厅基金资助项目;No.16ZB0125~~

摘　　要：目前临床观察发现肠易激综合征(irritable bowel syndrome,IBS)存在性别差异,且经流行病学调查结果证实IBS男女发病比例约为1∶2.而目前对于I B S机制的相关研究并未针对性别开展有针对性的研究,故我们通过查阅相关文献对可能影响该病性别差异的几种因素如性激素及其受体、促肾上腺皮质激素释放因子和免疫因素等进行整理分析,以期为阐释IBS发病的性别差异提供依据,以帮助明确IBS病因和发病机制,最终为临床靶向治疗提供更精准的策略.Clinically,it has been found that there exist sex differences in irritable bowel syndrome（IBS）.Epidemiological evidence confirms that the ratio of males to females with IBS is about1：2.Previous research on the mechanism of IBS rarely focused on such sex differences.In order to provide a basis for explaining the sex differences in IBS,the authors analyzed the relevant literature and found that several factors such as sex hormones and their receptors,corticotropin releasing factor and immune factors may cause such sex differences.The identification of these factors may help clarify the etiology and pathogenesis of IBS and provide a more accurate strategy for clinical targeted therapy.

关 键 词：肠易激综合征 性别差异 机制 

分 类 号：R574.4[医药卫生—消化系统]