14-3-3蛋白在人类疾病中的研究进展  

Role of 14-3-3 proteins in human diseases

作　　者：唐裕福[1] 张怡冰[2] 冯晓东[1] 林绅晖 乔娜[1] 孙忠怡 周文平[1] Yu-Fu Tang Yi-Bing Zhang Xiao-Dong Feng Shen-Hui Lin Na Qiao Zhong-Yi Sun Wen-Ping Zhou(Yu-Fu Tang, Xiao-Dong Feng, Shen-Hui Lin, Na Qiao, Zhong-Yi Sun, Wen-Ping Zhou, Department of Hepatobiliary Surgery, General Hospital of Shenyang Military Command, Shenyang 110016, Liaoning Province, China Yi-Bing Zhang, Medical Department, General Hospital of Shenyang Military Command, Shenyang 110016, Liaoning Province, Chin)

机构地区：[1]原沈阳军区总医院肝胆外科,辽宁省沈阳市110016 [2]原沈阳军区总医院医疗科,辽宁省沈阳市110016

出　　处：《世界华人消化杂志》2017年第6期509-520,共12页World Chinese Journal of Digestology

基　　金：国家自然科学基金青年科学基金资助项目,No.81602571;辽宁省博士启动基金资助项目,No.201603197~~

摘　　要：14-3-3蛋白家族是广泛存在于真核生物体内的一类小分子蛋白,其通过与配体蛋白结合,参与细胞信号转导、周期、凋亡、代谢、细胞骨架重组及细胞表型转化等重要生理活动的调节.目前研究显示,14-3-3蛋白的异常表达与诸多疾病的发生、发展密切相关.本文着重介绍了14-3-3蛋白的表达调控、生物学功能以及14-3-3蛋白在疾病中的作用.14-3-3 proteins are a family of highly conserved small proteins.By interacting with target proteins,14-3-3 proteins are involved in regulating multiple cellular processes,such as signal transduction,cell cycle regulation,apoptosis,cellular metabolism,cytoskeleton organization and malignant transformation.Mounting evidence suggests that 14-3-3 proteins play an important role in a wide variety of human diseases,such as human cancers and nervous system diseases.This review aims to summarize the current knowledge on the expression,regulation and biological function of 14-3-3 to highlight the role of 14-3-3 proteins in human diseases.

关 键 词：14-3-3蛋白 疾病 发病机制 

分 类 号：R363[医药卫生—病理学]