复方石斛冲剂对小鼠免疫调节作用的影响  

Effects of Dendrobium Compound Granules on Immune Function in Mice

作　　者：吴月国[1] 赵铮蓉[1] 张萍[1] 滕士元 赵锋 李青青[1] 刘骅[1] 

机构地区：[1]浙江省医学科学院,杭州310013 [2]苏州神元生物科技股份有限公司,江苏苏州215222

出　　处：《中国现代应用药学》2017年第2期182-185,共4页Chinese Journal of Modern Applied Pharmacy

基　　金：浙江省科技计划项目(2015F50017);浙江省医药卫生科技计划项目(201478211;2017186376);苏州市吴江区科技项目(WN201342)

摘　　要：目的研究复方石斛冲剂对小鼠的免疫调节作用的影响。方法 ICR小鼠随机分为对照组和复方石斛冲剂低、中、高剂量组(0.65,1.30,4.00 g·kg^(-1)),连续灌胃30~39 d后进行脏器/体质量比值测定、淋巴细胞转化试验、碳廓清试验、血清溶血素试验、迟发型变态反应试验、腹腔巨噬细胞吞噬鸡红细胞试验、抗体生成细胞检测及自然杀伤(natural-killer,NK)细胞活性试验。结果复方石斛冲剂能刺激淋巴细胞增殖;提高小鼠血清溶血素含量和迟发型变态反应水平;升高NK细胞活性;增强小鼠吞噬细胞吞噬鸡红细胞及碳廓清的能力。结论复方石斛冲剂具有一定的免疫增强作用。OBJECTIVE To study the effects of the Dendrobium compound granules on the immune function in mice. METHODS ICR mice were randomly divided into 4 groups, included 3 dosage groups （0.65, 1.30, 4.00 g.kg-1） and a negative control group. The spleen and thymus index, transformation level of lymphoid, carbon clearance index, the content of serum emolysin, the level of delayed type hypersensitivity（DTH）, the phagocytic ability of celiac macrophage, the number of antibody formation cell and activity of natural-killer （NK） cells were measured respectively after gavage for 30-39 d. RESULTS Dendrobium compound granules could stimulate the lymphocyte proliferation, increase hemolysin content and DTH level, activity of NK cells, promote the phagocytic rate obviously. CONCLUSION Dendrobium compound granules can enhance the immune function in mice.

关 键 词：复方石斛冲剂 铁皮石斛 免疫功能 

分 类 号：R285.5[医药卫生—中药学]