肾上腺皮质腺瘤组织中Calretinin、Melan-A和Inhibin α的表达及意义  

Expressions and Significance of Calretinin,Melan-A and Inhibin α in the Adrenal Cortical Adenoma

作　　者：侯卫华[1] 李从洋[1] 段尚林[1] 胡学信[1] 刘艳峰[1] HOU Weihua LI Congyang DUAN Shanglin HU Xuexin LIU Yanfeng(Department of Pathology,the 152th Hospital of PLA ,Pingdingshan 467000, China)

机构地区：[1]解放军第152中心医院病理科,河南平顶山467000

出　　处：《肿瘤基础与临床》2017年第1期15-19,共5页journal of basic and clinical oncology

摘　　要：目的探讨Calretinin、Melan-A和Inhibinα在肾上腺皮质腺瘤(ACA)组织中的表达及意义。方法采用免疫组化Max Vision两步法检测30例ACA、4例肾上腺皮质结节状增生、30例肾上腺良性嗜铬细胞瘤(ABP)、8例正常肾上腺组织中Calretinin、Melan-A和Inhibinα的表达。结果 Calretinin阳性率:ACA70.0%、肾上腺皮质结节状增生100.0%、ABP 13.4%、正常肾上腺皮质75.0%、正常肾上腺髓质0.0%;Melan-A阳性率:ACA 53.3%、肾上腺皮质结节状增生50.0%、ABP 3.3%、正常肾上腺皮质25.0%、正常肾上腺髓质0.0%;Inhibinα阳性率:ACA 83.3%、肾上腺皮质结节状增生100.0%、ABP 6.7%、正常肾上腺皮质100.0%、正常肾上腺髓质0.0%。Calretinin、Melan-A和Inhibinα在ACA组织中的表达显著高于ABP,差异有统计学意义(0.05)。三者或两两联合检测敏感性最高的是Calretinin与Inhibinα(76.7%)、特异性最高的是Melan-A与Inhibinα(95.0%)、准确性最高的是Calretinin与Inhibinα(83.3%)。结论 Calretinin、Melan-A和Inhibinα联合检测在ACA的诊断及其与ABP的鉴别诊断中具有重要价值。Objective To explore the expressions and significance of Calretinin, Melan-A and Inhibin α in the adrenal cortical adenoma （ACA）. Methods The expressions of Calretinin, Melan-A and Inhibin α in 30 cases of ACA,4 cases of adrenal nodular hyperplasia,30 cases of adrenal benign phaeochromoeytoma （ABP） and 8 cases of normal adrenal detected by immunohistochemical MaxVision method. Results Calretinin was positive in the 70.0% of ACA, 100.0% of adrenal nodular hyperplasia, 13.4% of ABP,75.0% of normal adrenal cortical and 0.0% of normal adrenal medulla; Melan-A was positive in the 53.3% of ACA ,50.0% of adrenal nodular hyperplasia ,3.3% of ABP,25.0% of normal adrenal cortical and 0. 0% of normal adrenal medulla; Inhibin α was positive in the 83.3% of ACA, 100.0% of adrenal nodular hyperplasia,6.7% of ABP, 100.0% of normal adrenal cortical and 0. 0% of normal adrenal medulla. The positive expression rate of Calretinin, Melan-A and Inhibin α protein in the ACA was significantly higher than that in the ABP, the difference was statistically significant （ P 〈 0.05 ）. Of combined detection of three or two of them, the sensitivity was highest in the Calretinin and Inhibin α （76.7%）, the specificity was highest in the Melan-A and Inhibin α （95.0%） ,the accuracy was highest in the Calretinin and Inhibin ct （83.3%）. Conclusion The combined detection of Calretinin, Melan-A and Inhibin α has the important practical value in the diagnosis of ACA and the differential diagnosis of ACA and ABP.

关 键 词：肾上腺皮质腺瘤 肾上腺良性嗜铬细胞瘤 CALRETININ MELAN-A Inhibinα 

分 类 号：R736.6[医药卫生—肿瘤] R730.23[医药卫生—临床医学]