神经血管单元在慢性脑低灌注致认知功能障碍中的作用  

Roles of neurovascular unit in cognitive impairment induced by chronic cerebral hypoperfusion

作　　者：王大鹏[1] 吴一芳 海舰[1] 

机构地区：[1]同济大学附属同济医院神经外科,上海200065

出　　处：《中华全科医师杂志》2017年第3期244-246,共3页Chinese Journal of General Practitioners

摘　　要：慢性脑低灌注可诱导神经血管单元损伤，是导致认知功能障碍的重要因素。神经血管单元由神经元、胶质细胞、血管性细胞和细胞外基质组成，其损伤可导致血脑屏障功能失调、细胞信号通路异常以及认知功能障碍，但分子作用机制尚不清楚。因此研究神经血管单元在慢性脑低灌注导致的认知功能障碍中的作用，将为认知功能障碍的治疗提供新的理论依据。Chronic cerebral hypoperfusion （CCH） may result in neurovascular unit （NVU） injury, causing cognitive impairment. The NVU consists of neurons, glial cells, vascular cells and extracellular matrix. The damage of NVU can induce the blood-brain barrier dysfunction, abnormal cell signaling, as well as cognitive impairment. However, its molecular mechanism is unclear. Thus, investigating the role of NUV in CCH-induced cognitive impairment may provide a theoretical basis for the novel treatment of cognitive impairment.

关 键 词：脑缺血 认知障碍 神经血管单元 

分 类 号：R749.1[医药卫生—神经病学与精神病学]