Effects of Yishengukang decoction on expression of bone-specific alkaline phosphatase,carboxyterminal propeptide of typeⅠprocollagen,and carboxyterminal cross-linked telepeptide of typeⅠcollagen in malignant tumor patients with bone metastasis  

作　　者：Yin Yukun Feng Li Zhou Lei Li Jie Gao Yin Wang Ningjun Yu Jianhua Jiang Zhenglong He Shengqi Lu Dianrong Wang Fang Du Yanlin 

机构地区：[1]Traditional Chinese Medicine Department of National Cancer Center/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China [2]He Shengqi,Lu Dianrong,Wang Fang,Du Yanlin,Oncology Department of Wangjing Hospital,China Academy of Chinese Medical Sciences,Beijing 100102,China

出　　处：《Journal of Traditional Chinese Medicine》2017年第1期30-34,共5页中医杂志（英文版）

基　　金：Wangjing Hospital,China Academy of Chinese Medical Sciences Program:Clinical Study on Improving the Life Quality of Cancer Patients by Nourishing Yin and Tonifying the Kidney(No.2007-01);Specific Science and Technology Improvement Project of Beijing Traditional Chinese Medical Science and Technology Development Fund:Clinical Study on Chinese Herbs of Bushen Huayu Combined with Hyperthermia in Treating Bone Metastatic Pain(No.KJTS2011-13);Beijing Science and Technology Program"the Capital of special":Clinical Study on Chinese Herbs of Fuzheng Jiedu Huayu in Treating Cancer Pain(Z141107002514045)

摘　　要：OBJECTIVE: To investigate the effect of Yishengukang decoction on the expression of the metabolic bone markers, bone-specific alkaline phosphatase(BAP), carboxyterminal propeptide of type Ⅰ procollagen(PICP), and carboxyterminal cross-linked telepeptide of type Ⅰ collagen(ICTP), in cancer patients with bone metastasis.METHODS: Patients(n = 180) were divided into three groups:(a) bone metastasis patients treated with Yishengukang and pamidronate disodium injection(treatment group, n = 60);(b) bone metastasis patients treated with pamidronate disodium injection alone(control group, n = 60);(c) cancer patients without metastatic bone lesion(non-bone metastasis group, n = 60). Serum levels of the metabolic markers BAP, PICP, and ICTP were detected by enzyme-linked immunosorbent assay pre- and post-therapy.RESULTS: A significant decrease in serum BAP level was observed in the treatment group compared with the control group. However there were no significant differences in serum levels of PICP and ICTP before or after treatment compared with the control group.CONCLUSION: Yishengukang decoction combined with pamidronate disodium injection reduced serum BAP level to a greater extent that pamidronate disodium injection alone. Furthermore, the combined therapy was more beneficial in regulating imbalanced bone metabolism after bone metastasis,and may represent the molecular mechanism underpinning the effects of Yishengukang decoction.OBJECTIVE： To investigate the effect of Yishengu-kang decoction on the expression of the metabolic bone markers, bone-specific alkaline phosphatase （BAP）, carboxyterminal propeptide of type I pro-collagen （PICP）, and carboxyterminal cross-linked telepeptide of type I collagen （ICTP）, in cancer pa- tients with bone metastasis, METHODS： Patients （n = 180） were divided into three groups： （a） bone metastasis patients treated with Yishengukang and pamidronate disodium injection （treatment group, n = 60）; （b） bone metastasis patients treated with pamidronate disodium injection alone （control group, n = 60）; （c）cancer patients without metastatic bone lesion （non-bone metastasis group, n = 60）. Serum levels of the meta-bolic markers BAP, PICP, and ICTP were detected by enzyme-linked immunosorbent assay pre- and post-therapy. RESULTS： A significant decrease in serum BAP level was observed in the treatment group compared with the control group. However there were no significant differences in serum levels of PICP and ICTP before or after treatment compared with the control group. CONCLUSION： Yishengukang decoction combined with pamidronate disodium injection reduced serum BAP level to a greater extent that pamidronate disodium injection alone. Furthermore, the combined therapy was more beneficial in regulating imbalanced bone metabolism after bone metastasis, and may represent the molecular mechanism underpinning the effects of Yishengukang decoction.

关 键 词：Malignant tumor Neoplasm metastasis Alkaline phosphatase Collagen type Ⅰ 

分 类 号：R738[医药卫生—肿瘤]