比格犬蠕形螨病的诊疗与病理组织学观察  

Treatment and pathological observation of demodex canis in beagle dogs

作　　者：温福利[1] 徐洪齐 熊爱兰 马雷[1] 张诗兰[1] 郑和平[1] 

机构地区：[1]南京军区福州总医院比较医学科,福州350025 [2]福州动物缘宠物医院,福州35001

出　　处：《中国比较医学杂志》2017年第1期27-31,共5页Chinese Journal of Comparative Medicine

基　　金：福建省科技计划引导性项目(2015Y0075);南京军区福州总医院临床应用研究专项(2015L01)

摘　　要：目的对感染蠕形螨的比格犬进行诊疗及病理组织学观察。方法直接涂片法进行显微镜检查,常规石蜡切片及HE染色后进行病理组织学观察。结果 (1)临床观察:患病犬四肢、眼周、下腹部等部位皮肤出现红点,患部脱毛,四肢皮肤变厚起皱褶;(2)血液常规检查:基本正常;(3)显微镜观察:发现大量犬蠕形螨小型虫体和虫卵;(4)病理组织学观察:毛囊内见大量犬蠕形螨虫体和虫卵,皮脂腺和汗腺结构正常,均未见螨体寄生。毛囊周围见大量嗜酸性粒细胞和嗜中性粒细胞浸润,同时可见多灶性肉芽肿形成,肉芽肿呈椭圆形;(5)治疗方案:采用联合用药进行治疗,加强环境控制,疗效显著。结论犬蠕形螨引起的肉芽肿可划分为免疫性肉芽肿;小型虫体感染后可能不会破坏皮脂腺,皮脂腺是否感染虫体可能与虫体种类或感染病程相关。Objective Treatment and histopathological observation of demodex canis in beagle dogs. Methods Using the method of direct smear for microscopic examination of demodex canis. Histopathologieal observation on the skin of the parasitic parts after routine paraffin section and HE staining. Results （ 1 ） Clinical observation ： The red spots and hair removal was appeared on limbs, eyes, lower abdomen and other parts of the skin of canine patients. The skin of the limbs becomes thicker and wrinkles. （2） Blood routine examination： Basically normal. （3） Microscope observation： The results showed that a large number of worms and eggs of small demodex canis could be found. （4） Histopathological observation ： Hair follicles showed a large number of demodex mites and eggs. The sebaceous glands and sweat glands have normal morphology and no mites was found. A large number of eosinophils and neutrophil infiltration were seen around the hair follicles. It was also found that the formation of multifocal granuloma ： the granuloma was oval shaped. （5） Treatment programme ： The combination of medication and the strengthening of environmental control has been shown to be effective. Conclusions Granuloma caused by demodex canis can be divided into immune granuloma. It may not be possible to destroy the sebaceous glands after infection with small demodex canis. Whether the sebaceous gland is infected with the demodex canis may be associated with the worm species or course of disease.

关 键 词：犬蠕形螨 皮脂腺 肉芽肿 

分 类 号：R-332[医药卫生]