阿加曲班联合氯吡格雷治疗大动脉粥样硬化性脑梗死的临床效果分析  

Analysis of the clinical effect of argatroban combined with clopidogrel in treatment of large artery atherosclerotic cerebral infarction

作　　者：朱英标[1] 官常荣[2] 叶祖森[3] 汤亚男[1] 

机构地区：[1]浙江省丽水市人民医院神经内科,浙江丽水323000 [2]浙江省丽水市人民医院内分泌科,浙江丽水323000 [3]温州医科大学附属第一医院神经内科,浙江温州325000

出　　处：《中国现代医生》2017年第1期64-67,共4页China Modern Doctor

基　　金：浙江省自然科学基金项目(LY17H090016);浙江省丽水市科技计划项目(2013JYZB44)

摘　　要：目的分析阿加曲班联合氯吡格雷治疗大动脉粥样硬化性脑梗死的临床效果。方法选择2015年1月~2016年3月至我院就诊的86例大动脉粥样硬化性脑梗死患者,分为常规组与实验组,每组患者各43例,其中常规组患者采取氯吡格雷治疗,实验组患者在此基础上加用阿加曲班进行治疗,对比两组患者的治疗效果。结果实验组与常规组的治疗总有效率分别为93.02%与72.09%,差异有统计学意义(P<0.05);治疗前两组患者的NIHSS评分无明显差异(P>0.05),治疗后1周、2周实验组患者的评分明显低于常规组(P<0.05);实验组与常规组治疗前血小板聚集率比较无显著差异(P>0.05),治疗后第1周和第2周两组患者的血小板聚集率明显下降(P<0.05),治疗后两组患者无显著性差异(P>0.05)。实验组与常规组的不良反应发生率分别为6.98%与9.30%,差异无统计学意义(P>0.05)。结论对大动脉粥样硬化性脑梗死患者采取阿加曲班联合氯吡格雷进行治疗的效果较为显著,可有效改善患者神经功能缺损情况,值得在今后的临床工作中实践推广。Objective To evaluate the clinical effect of argatroban combined with clopidogrel in the treatment of large artery atherosclerotic cerebral infarction.Methods A total of 86 patients with large artery atherosclerotic cerebral infarction who were diagnosed in our hospital from January 2015 to March 2016 were selected.They were divided into the conventional group and the experimental group,with 43 patients in each group.The patients in the conventional group was given clopidogrel for the treatment.The patients in the experimental group was given argatroban for the treatment on the basis of the conventional group.The therapeutic effects were compared between the two groups.Results The total effective rates were 93.02%and 72.09%in the experimental group and the conventional group respectively（P〉0.05）;there was no significant difference in NIHSS score between the two groups before treatment（P〉0.05）.After 1 week and 2 weeks of treatment,the score in the experimental group was significantly lower than that in the conventional group（P〉0.05）;there was no significant difference between the experimental group and the conventional group in the platelet aggregation rate before treatment（P〉0.05）.At 1 week and 2 weeks after treatment,the platelet aggregation rate of the two groups was significantly decreased（P〈0.05）.There was no significant difference between the two groups after treatment（P〉0.05）.The incidence rate of adverse reactions was 6.98%and 9.30%in the experimental group and the conventional group respectively（P〉0.05）.Conclusion Argatroban combined with clopidogrel in the patients with large artery atherosclerotic cerebral infarction has a significant therapeutic effect.It can effectively improve the neurological deficit in the patients,which is worthy to be popularized in future clinical work.

关 键 词：大动脉粥样硬化性脑梗死 阿加曲班 氯吡格雷 

分 类 号：R743.3[医药卫生—神经病学与精神病学]