小细胞肺癌组织中LncRNA EXOC7的表达及其与预后的关系  

The relationship between the expression of LncRNA EXOC7 and the prognosis of patients with small cell lung cancer

作　　者：曾丽[1] 杨濡溪[1] 王佳[1] 刘宇[1] 白义凤[1] 

机构地区：[1]四川省医学科学院.四川省人民医院肿瘤中心,四川成都610072

出　　处：《肿瘤》2017年第3期269-274,280,共7页Tumor

摘　　要：目的:探讨小细胞肺癌(small cell lung cancer,SCLC)组织中长链非编码RNA外泌体复合物7(long non-coding RNA exocyst complex component 7,Lnc RNA EXOC7)的表达及其临床意义。方法:应用实时荧光定量PCR法检测86例SCLC组织、35例癌旁组织及51例正常肺组织中LncRNA EXOC7的表达,分析LncRNA EXOC7表达与SCLC患者临床病理特征及预后的关系。结果:SCLC组织中LncRNA EXOC7的表达水平明显高于癌旁组织及正常肺组织(P值均<0.001)。LncRNA EXOC7表达与SCLC患者的疾病分期、淋巴结转移、远处转移、化疗疗效及复发有关(P值均<0.05)。高表达LncRNA EXOC7患者的总生存时间及无进展生存时间均短于低表达者(P值均<0.001)。LncRNA EXOC7表达、疾病分期、远处转移及复发是SCLC患者预后的独立影响因素(P值均<0.05)。结论:LncRNA EXOC7参与调节SCLC的发生和发展,可能成为潜在的SCLC患者预后评估的分子标志物。Objective： To investigate the expression of long non-coding RNA exocyst complex component 7 （LncRNA EXOCT） in small cell lung cancer （SCLC） tissues and its clinical significance. Methods： The expressions of LncRNA EXOC7 in 86 cases of SCLC tissues, 35 cases of para-cancerous tissues and 51 cases of normal lung tissues were detected by real-time fluorescent quantitative PCR. The relationship between the expression of LncRNA EXOC7 and the clinicalpathological characteristics and prognosis of patients with SCLC was analyzed. Results： The expression level of LncRNA EXOC7 in SCLC tissues was higher than that in para-cancerous tissues and normal lung tissues （both P 〈 0.001）. LncRNA EXOC7 expression was positively correlated with disease stage, lymph node metastasis, distant metastasis, response to chemotherapy and recurrence （all P 〈 0.05）. The overall survival time and progression-free survival time of patients with high expression level of LncRNA EXOC7 were shorter than those with low expression level of LncRNA EXOC7 （both P 〈 0.001）. LncRNA EXOC7 expression, disease stage, distant metastasis and recurrence were independent prognostic features for patients with SCLC （all P 〈 0.05）. Conclusion： LncRNA EXOC7 is involved in the development of SCLC, and may be used as a molecular marker for the evaluation of prognosis of SCLC.

关 键 词：小细胞肺癌 RNA 长链非编码 预后 

分 类 号：R734.2[医药卫生—肿瘤]