丁螺环酮治疗抗精神病药物所致的性功能障碍疗效研究  

Therapeutic effect of buspirone in treatment of sexual dysfunction induced by antipsychotic drugs

作　　者：闻传毅 张彬[1] 李霞[1] 马榕杏 WEN Chuanyi ZHANG Bin LI Xia et al.(Jingzhou Mental Health Center, Jingzhou 434000, Chin)

机构地区：[1]荆州市精神卫生中心,湖北荆州434000

出　　处：《西北国防医学杂志》2017年第2期114-117,共4页Medical Journal of National Defending Forces in Northwest China

摘　　要：目的:探究丁螺环酮治疗抗精神病药物所致性功能障碍的临床疗效,为抗精神病药物所致性功能障碍的临床治疗提供帮助。方法:选取我院收治的180例抗精神病药物所致性功能障碍患者,按随机数字表法分为观察组和对照组,每组各90例。对照组给予安慰剂治疗,观察组给予丁螺环酮治疗,治疗前后比较两组患者的临床疗效及两组女性患者性功能指数(FSFI)调查问卷得分和男性患者国际勃起功能指数(IIEF-5)调查问卷得分。结果:观察组患者经丁螺环酮治疗后,总缓解率达83.33%,显著高于对照组的25.56%,缓解率比较差异均有统计学意义(P<0.05)。治疗前,两组女性患者FSFI各项得分及总分和两组男性患者IIEF-5各项得分及总分比较,差异无统计学意义(P>0.05);观察组女性患者经丁螺环酮治疗后,FSFI各项(性欲程度、阴道润滑状况、性高潮状况、性满意度)得分和总分显著高于对照组,组间分数比较,差异有统计学意义(P<0.05);观察组男性患者经丁螺环酮治疗后,IIEF-5各项(问题1~5)得分和总分显著高于对照组,组间分数比较,差异有统计学意义(P<0.05)。结论:抗精神病药物所致性功能障碍患者经丁螺环酮治疗后各项指标均得到改善,为抗精神病药物所致性功能障碍患者的临床治疗提供帮助。Objective：To observe the therapeutic effect of buspirone in treatment of sexual dysfunction induced by antipsychotic drugs and offer help to sexual dysfunction therapy.Methods：A total of 180 patients with sexual dysfunction induced by antipsychotic drugs were selected and randomly divided into two groups：the observation group（n=90）and the control group（n=90）.The patients in the control group were treated with placebo and the patients in the observation group were treated with buspirone.Before and after treatment,the clinical efficacy of the two groups and the scores of the two groups of female patients with FSFI questionnaire and the scores of the male patients with IIEF-5questionnaire were compared.Results：After treatment,the total remission rate of observation group was 83.33%,which was significantly higher than that of control group 25.56%（P〈0.05）.Before treatment,the female patients of two groups with FSFI questionnaire and the total score and the male patients of two groups with IIEF-5questionnaire scores and total score comparison was not statistically significant（P〈0.05）.In the control group,after treatment,the scores and total score of the FSFI questionnaire were significantly higher than those of the control group（P〈0.05）.In the control group,after treatment,the scores and total score of the IIEF-5questionnaire were significantly higher than those in the control group（P〈0.05）.Conclusion：The indexes of the patients with sexual dysfunction caused by antipsychotic drugs were improved after buspirone treatment,which can provide help for the clinical treatment to the patients with sexual dysfunction.

关 键 词：性功能障碍 丁螺环酮 调查问卷 

分 类 号：R749.3[医药卫生—神经病学与精神病学] R698[医药卫生—临床医学]