紫杉醇诱导化疗在局部晚期非小细胞肺癌治疗中的效果观察  

Efficacy of Paclitaxel induced chemotherapy for locally advanced non-small cell lung cancer

作　　者：邵艳[1] 刘桂荣[1] 张建国[1] 马兆明[1] Shaoyan et al(Radiotherapy Department, the Second People＇s Hospital, Lianyungang 222023, Chin)

机构地区：[1]连云港市第二人民医院放疗科,江苏222023

出　　处：《齐齐哈尔医学院学报》2016年第34期4279-4281,共3页Journal of Qiqihar Medical University

摘　　要：目的研究诱导化疗用于局部晚期非小细胞肺癌治疗的疗效。方法选取2011年1月至2012年1月本院收治的80例局部晚期非小细胞肺癌患者,随机分成观察组和对照组,各40例,对照组直接实施同步放化疗治疗,观察组在同步放化疗前行1个周期的诱导化疗治疗,比较两组近、远期疗效和毒副反应。结果观察组总缓解率为72.5%,较对照组的45.0%高(P<0.05),差异有统计学意义;观察组3年生存率为57.5%,较对照组的30.0%高(P<0.05),差异有统计学意义;观察组毒副反应较对照组少,但差异没有统计学意义(P>0.05)。结论局部晚期非小细胞肺癌在同步放化疗前进行诱导化疗可加强肿瘤病情的控制效果,提高临床疗效和患者生存率,且不会增加毒副反应,值得采用。Objective To evaluate the efficacy of induction chemotherapy for locally advanced non-small cell lung cancer. Methods Eighty patients with locally advanced non-small cell lung cancer were enrolled from January 2011 to January 2011 ,randomly divided into observation group and control group. Control group patients were administered with chemoradiotherapy, but observation group patients were given one cycles induction chemotherapy before chemoradiotherapy. Results The response rate was 72.50% in observation group, and 45.00% in control group. Difference was significant between the two groups, P〈0. 05. 3 year survival rate was 57.50% in observation group and 30.00% in the control group（ P〈0.05 ）. There was no significant difference in rates of adverse reaction in the two groups （P〉 0. 05 ）. Conclusions Induction chemotherapy in patients with locally advanced non-small cell lung cancer before chemotherapy can enhance the control of the disease, improve the clinical efficacy and survival rate of patients, and will not increase the side effects, which is worth adopting.

关 键 词：局部晚期非小细胞肺癌 同步放化疗 诱导化疗 

分 类 号：R734.2[医药卫生—肿瘤]