海洛因依赖者注意转换过程中持续性注意功能  

Impaired sustained attention function of heroin abusers in attention switching

作　　者：李慧莉[1] 耿梦文 盛利霞[2] 崔敏[2] 赵丽[2] 李俊发[2] 罗艳琳[2] LI Huili GENG Mengwen SHENG Lixia CUI Min ZHAO Li LI Junfa LUO Yanlin(Department of Neurology, Capital Medical University, Beijing 100069, China.)

机构地区：[1]首都医科大学基础医学院,2012级临床医学北京100069 [2]首都医科大学基础医学院神经生物学系

出　　处：《中国神经精神疾病杂志》2016年第12期726-730,共5页Chinese Journal of Nervous and Mental Diseases

基　　金：首都医科大学基础临床合作课题(编号:14JL01,15JL56);第二课堂项目(编号:D2KT2015,D2KT2016);本科生科研创新项目(编号:XSKY-2015,XSKY2016);长学制导师项目(编号:7NZDS2016)

摘　　要：目的探究海洛因依赖对依赖者注意转换过程的影响。方法采用任务转换范式对36例戒断维持治疗的海洛因依赖者(男33例,女3例)和36名正常对照(男32名,女4名)的持续性注意和转换性注意功能进行评估,分别记录持续性试次和转换性试次的反应时和正确率。结果海洛因依赖组在持续性注意和转换性注意条件下的反应时、正确率均无统计学差异(P>0.05),无转换代价不明显。对照组在持续性注意条件下的反应时短于转换性注意条件[(695.3±95.9)ms vs.(780.3±93.3)ms,P<0.05],且正确率较高[(98.0%±2.2%)vs.(93.8%±5.0%),P<0.05],反应时和正确率均存在明显转换代价。对照组转换代价值高于海洛因依赖组[反应时:(85.1±92.4)ms vs.(19.7±66.8),P<0.05;正确率:(4.2%±4.6%)vs.(1.1%±4.4%),P<0.05]。在持续性注意条件下,海洛因依赖组的反应时长于对照组[(791.6±74.3)ms vs.(695.3±95.9)ms,P<0.05],正确率低于对照组[(92.5%±8.4%)vs.(98.0%±2.2%),P<0.05]。结论海洛因依赖者未表现出对照组存在的转换代价,可能与海洛因依赖者的持续性注意功能受损有关。Objective To investigate the effect of heroin abuse on attention switching. Methods Thirty-six Heroin abusers （33 males, 3 females） and 36 controls （32 males, 4 females） were enrolled in the study. Their cognitive function was tested by using the Switching Task, including Sustained Attention trials and Switching Attention trials. The reaction time and accuracy were recorded separately by the computer. Results The accuracy or reaction times were not signifi- cantly different between Switching Attention trial and Sustained Attention trial in heroin abusers, suggesting a lower Switch Costs value compared to the healthy controls [（19.7±66.8） ms vs. （85.1±92.4） ms]. The healthy controls showed faster reaction speed [Sustained Attention trial （695.3±95.9） ms vs. Switching Attention trial （780.3±93.3） ms, P〈0.05] and higher accuracy [Sustained Attention trial （98.0%±2.2%） .vs. Switching Attention trial （93.8%±5.0%）, P〈0.05] under the Sustained Attention trial. Compared with the healthy controls, the heroin abusers showed slower reaction speed [（791.6 ±74.3） ms vs. （695.3±95.9） ms, P〈0.05] and lower accuracy [（92.5%±8.4%） vs. （98.0%±2.2%）, P〈0.05] in Sustained Attention trial, but not in Switching Attention trial. Conclusions The present study has revealed absence of Switch Costs in heroin abusers, which may be related to the damage of heroin abusers in their Sustained Attention function.

关 键 词：海洛因依赖 任务转换 注意转换功能 转换代价 

分 类 号：R749.64[医药卫生—神经病学与精神病学]