E-钙黏附蛋白在乳腺浸润性导管癌中表达的分析  

Expression of E-calcium binding protein in invasive ductal carcinoma of breast

作　　者：杨亮[1] 王斌[1] 朱丽萍[1] 吴涛[1] 赵倩[1] 迪力夏提.金斯汗 杜露[1] 王波[1] 王喜艳[1] 

机构地区：[1]新疆医科大学附属肿瘤医院乳腺外科一病区,乌鲁木齐830011

出　　处：《安徽医科大学学报》2017年第3期397-400,共4页Acta Universitatis Medicinalis Anhui

基　　金：新疆维吾尔自治区自然科学基金项目(编号:2016D01C353)

摘　　要：目的探讨乳腺浸润性导管癌中E-钙黏附蛋白(Ecadherin)的表达及其相关因素。方法采用免疫组织化学方法检测30例良性乳腺组织及450例乳腺浸润性导管癌病理组织切片中E-cadherin的表达情况,采用χ2检验及Logistic回归分析影响E-cadherin表达的影响因素及临床意义。结果 30例纤维腺瘤中E-cadherin均呈高表达,E-cadherin在157例无转移的癌组织中有77例高表达,高表达率为49.04%(77/157),293例有转移的癌组织中87例高表达,高表达率为29.69%(87/293),两组差异有统计学意义(χ2=16.53,P=0.001),E-cadherin免疫组化染色高表达和低表达在年龄、淋巴结是否转移、肿块大小、ER表达、分子分型及肿瘤组织学分级中差异有统计学意义(P<0.05),而在肿瘤分期、是否绝经、Cerb B-2及Ki-67表达情况中差异无统计学意义,Logistic回归分析提示:淋巴结是否转移、肿块大小、ER表达、分子分型及肿瘤细胞组织学分级是影响E-cadherin表达的影响因素。结论 E-cadherin表达与淋巴结是否转移、ER表达、分子分型及肿瘤组织学分级相关。Objective To investigate the expression of E-calcium binding protein （E-cadherin） in invasive ductal carcinoma of breast and its related factors. Methods The immunohistochemical method was used to detect E-cad- herin expression in 30 cases of benign breast tissue and 450 cases of breast invasive ductal carcinoma, using the chi-square test and logistic regression analysis of factors influencing the effects of E-cadherin expression and its clin- ical significance. Results 30 cases of breast fibroadenoma were positive expression of E-cadherin; E-cadherin high expression was 49.04% （77/157） in 157 cases of non metastaticbreast cancer; E-cadherin high expression was 29.69% （87/293） in lymph node metastasis of 293 cases breast cancer. The expression of E-cadherin in breast cancer without lymph node metastasis and lymph node metastasis group had significant difference （X2 = 16.53, P =0. 001 ）. E-cadherin high expression and low expression in age, lymph node metastasis, tumor size, ER expression and molecular typing and tumor grade were statistically significant （P 〈 0. 05 ）, but in tumor staging and menopause, CerbB-2, Ki-67 expression, the difference were not statistically significant. Logistic regression a- nalysis showed that lymph node metastasis, tumor size, ER expression, molecular typing and grading of tumor cells were the factors influencing the effects of E-cadherin expression. Conclusion E-cadherin expression is related to lymph node metastasis, ER expression, molecular typing and tumor grade.

关 键 词：乳腺癌 E-钙黏蛋白 淋巴结转移 分子分型 

分 类 号：R735.9[医药卫生—肿瘤]