血清外体RNA及甲胎蛋白对胎盘植入的诊断价值  

Diagnostic Value of Serum Exosomal RNA and AFP in Placenta Accreta

作　　者：赵雅堃 武红利[2] 康文丽[2] 苏媛媛[2] 李雅钗[2] 李瑞[2] ZHAO Yakun WU Hongli KANG Wenli SU Yuanyuan LI Yachai LI Rui(Hebei University, Baoding 071000, Hebei, China Department of Obstetrics, Affiliated Hospital of Hebei University, Baoding 071000, Hebei, China)

机构地区：[1]河北大学,河北保定071000 [2]河北大学附属医院产科,河北保定071000

出　　处：《贵州医科大学学报》2017年第3期344-347,共4页Journal of Guizhou Medical University

基　　金：河北省科技成果重点推广计划项目(16ZF079)

摘　　要：目的:探讨孕妇血清外体RNA(exosomal RNA)及甲胎蛋白(AFP)对诊断胎盘植入的价值。方法:凶险性前置胎盘的单胎孕妇76例,根据胎盘是否植入分为植入组(n=32)与非植入组(n=44),另选取既经有剖宫产史,此次妊娠胎盘位置正常且无其他妊娠合并症或并发症的单胎孕妇50例作为对照组;收集3组孕妇年龄、孕次、产次、剖宫产次及孕周等资料,并于入院时抽取孕妇静脉血,测定血清AFP水平;提取血清中的exosomal RNA,测定其浓度。结果:3组孕妇年龄、孕次、产次、剖宫产次及孕周比较,差异无统计学意义(P>0.05),植入组孕妇血清exosomal RNA及AFP浓度高于非植入组及对照组,差异有统计学意义(P<0.05),而非植入组与对照组比较差异无统计学意义(P>0.05)。结论:监测前置胎盘的单胎孕妇血清中exosomal RNA及AFP水平有助于产前诊断胎盘植入。Objective：To investigate the value of serum exosomal RNA and AFP in the diagnosis of placenta accreta. Methods：76 pregnant women with risky placenta previa were divided into two groups：placenta accreta group（ 32 cases）,and non-placental implant group（ 44 cases）. In addition,50 pregnant women with singleton diagnosed as normal placenta site and no pregnancy complications as control group. The 3 groups of pregnant women were compared in terms of age,pregnancy times,birth times,cesarean section times,and gestational weeks,and collected venous blood when admitted to hospital; testing the level of serum AFP,then serum exosomal RNA was extracted and the concentration of exosomal RNA was determined. Result：There was no significant difference among the 3 groups of the general situation（ P〉0. 05）. The concentration of exosomal RNA and AFP in the implanted group were significantly higher than those in the non-implanted group and the control group,the difference was statistically significant（ P〈0. 05）,but there was no significant difference between the nonimplanted group and the control group（ P〉0. 05）. Conclusion：Monitoring level of exosomal RNA and AFP of placenta previa singleton pregnant women would be helpful for prenatal diagnosis of placenta accreta.

关 键 词：前置胎盘 孕妇 外体RNA 甲胎蛋白 产前诊断 

分 类 号：R714.2[医药卫生—妇产科学] R719[医药卫生—临床医学]