2型糖尿病合并胃食管反流患者血清胃泌素水平分析  

A study on the level of gastrin in patients with type 2 diabetes mellitus and gastroesophageal reflux disease

作　　者：何素玉[1] 刘益均[1] 陈拥军[1] 唐毅[1] 徐建玉[1] 吴艳[1] 

机构地区：[1]遂宁市中心医院消化内科,四川遂宁629000

出　　处：《华西医学》2017年第3期383-386,共4页West China Medical Journal

摘　　要：目的探讨2型糖尿病合并胃食管反流(gastroesophageal reflux disease,GERD)患者血清胃泌素水平,分析其在2型糖尿病合并GERD患者中的可能作用。方法选取2013年1月—2015年1月收治的38例2型糖尿病合并GERD患者作为A组,40例单纯2型糖尿病患者作为B组,36例单纯GERD患者作为C组,40名同期医院体检中心的健康人员作为D组。对4组研究对象空腹血清胃泌素水平进行测定并对比分析。结果 A组空腹血清胃泌素水平[(116.53±22.02)pg/m L]呈高分泌状态,较B、C、D组[(101.89±20.76)、(90.04±21.16)、(92.48±19.69)pg/m L]明显升高,差异有统计学意义(P<0.01);B组较C、D组胃泌素水平升高,差异有统计学意义(P<0.05);C、D组胃泌素水平比较,差异无统计学意义(P>0.05)。结论 2型糖尿病合并GERD患者血清胃泌素呈高分泌状态。胃泌素分泌异常可能与2型糖尿病合并GERD的发生发展有着密切联系。Objective To investigate the gastrin level in patients with type 2 diabetes mellitus （T2DM） with gastroesophageal reflux disease （GERD）, and analyze the possible mechanism of gastrin in the pathogenesis of T2DM combined with GERD. Methods Thirty-eight patients with T2DM combined with GERD treated between January 2013 and January 2015 were designated as group A; 40 patients with T2DM only were regarded as group B; 36 patients with GERD only were regarded as group C; and another 40 healthy volunteers who underwent physical examination at the same period were regarded as group D. The fasting serum levels of gastrin were measured and compared among the above four groups. Results The fasting serum level of gastrin was significantly higher in group A [（116.53±22.02） pg/mL] than group B [（101.89±20.76） pg/mL], group C [（90.04±21.16） pg/mL], and group D [（92.48±19.69） pg/mL] （P〈0.01）. The fasting serum level of gastrin in group B was significantly higher than group C and D （P〈0.05）. There was no significant difference between group C and D in terms of fasting serum level of gastrin （P〉0.05）. Conclusions There is a high level of gastrin in patients with GERD combined with T2DM. Abnormal secretion of gastrin may be closely related with the occurrence and development of T2DM and GERD.

关 键 词：2型糖尿病 胃食管反流 胃泌素 

分 类 号：R571[医药卫生—消化系统] R587.1[医药卫生—内科学]