子宫颈人乳头瘤病毒感染与宫颈癌的相关性  

Correlation of cervical human papillomavirus infection and cervical cancer

作　　者：范丰田 安百芬 袁启霞[1] 

机构地区：[1]日照市中医医院妇科,日照市276800

出　　处：《中华实验和临床感染病杂志（电子版）》2017年第1期81-84,共4页Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition)

摘　　要：目的分析子宫颈人乳头瘤病毒(HPV)感染与宫颈癌发病的相关性。方法选取本院2010年1月到2014年1月宫颈癌患者共80例,根据患者病理学诊断分为宫颈癌组和癌前病变组,另选取宫颈炎患者40例作为对照组,分析各组患者HPV感染与宫颈癌发生的相关性。结果癌前病变组和宫颈癌组患者HPV阳性率分别为62.50%和192.75%,均显著高于对照组(10%)(χ~2=25.365、P<0.001,χ~2=50.032、P<0.001)。对照组患者阳性HPV高危率(0.00%)显著低于癌前病变组(53.33%)和宫颈癌组(93.33%)(χ~2=4.030、P=0.045,χ~2=12.273、P<0.001);宫颈癌组患者HPV阳性的高危率显著高于癌前病变组(χ~2=114.425、P<0.001)。HPV与宫颈癌的相关性分析结果显示,HPV感染(OR=2.063、95%CI:2.011~2.124)和高危HPV感染(OR=1.032、95%CI:1.005~1.114)均与宫颈癌发生呈正相关,差异均具有统计学意义(P=0.001、0.033)。结论宫颈人乳头瘤病毒感染与宫颈癌发生呈正相关,有效筛查能够早期发现宫颈癌,以做好防控措施。Objective To investigate the correlation of human papillomavirus（HPV） infection and cervical cancer.Methods Total of 80 patients with cervical cancer in our hospital from January 2010 to January 2014 were selected,and were divided into cervical carcinoma group and precancerous lesion group according to pathologic diagnose.Meanwhile,40 healthy cases were selected as the control group.Results The positive rates of HPV in precancerous lesion group and cancer group were 62.50%and 92.75%,respectively,which were significantly higher than that of the control group（10%）（x^2 = 25.365,P〈0.001;x^2 =50.032,P〈0.001）.The high risk rate of HPV in patients of control group was only 0.00%,significantly lower than those of the precancerous lesion group（53.33%） and cervical cancer group（93.33%）（x^2 = 4.030,P =0.045;x^2 = 12.273,P〈0.001）.The high risk rate of HPV infection in cervical cancer group was significantly higher than that of the precancerous lesions group（x^2= 114.425,P〈0.001）.The analysis of correlation between HPV infection and cervical cancer showed that HPV infection（OR = 2.063,95%CI：2.011-2.124）and high risk of HPV infection（OR= 1.032,95%CI：1.005-1.114） were both positive correlated with cervical cancer,with significant differences.Conclusions The cervical HPV infection was positively correlated with cervical cancer.Effective screening approach should be applied to make cervical cancer early detected,and well prevention and control measures should be taken.

关 键 词：人乳头瘤病毒 宫颈癌 宫颈上皮内瘤变 相关性 

分 类 号：R737.33[医药卫生—肿瘤]