前列地尔联合灯盏细辛对脑梗死并糖尿病患者血清同型半胱氨酸的影响  

Effects of Prostaglandin Combined with Erigeron Breviscapus on Serum Homocysteine Level in Treatment of Diabetic Patients with Cerebral Infarction

作　　者：于建敏[1] 徐燕杰[1] 耿纪录[1] 李秦[1] 范艳平[2] YU Jian-min XU Yan-jie GENG Ji-lu Qin FAN Li-ping(Out-patient Department, 309 Hospital of PLA, Bei- jing 100091, China Department of Cadre Wards, Bethune International Peace Hospital of PLA, Shijiazhuang 050082, China)

机构地区：[1]解放军309医院门诊部,北京100091 [2]解放军白求恩国际和平医院干部病房,石家庄050082

出　　处：《临床误诊误治》2017年第3期92-94,共3页Clinical Misdiagnosis & Mistherapy

基　　金：2015年河北省科技计划项目(152777217)

摘　　要：目的探讨前列地尔和灯盏细辛对脑梗死并糖尿病患者血清同型半胱氨酸(homocysteine,Hcy)水平的变化及对疾病的影响。方法选择2014年9月—2015年9月我院收治的脑梗死并糖尿病45例(治疗组),予灯盏细辛和前列地尔治疗2周;选取同期在我院体检健康的42例(对照组)。比较两组血清Hcy和空腹血糖的水平变化及高Hcy血症发生率,观察前列地尔和灯盏细辛的疗效及不良反应。结果与对照组比较,治疗组治疗前后血清Hcy和空腹血糖的水平及高Hcy血症发生率均明显升高,差异有统计学意义(P<0.05);与治疗前比较,治疗后血清Hcy水平及高Hcy血症发生率均明显下降(P<0.05),空腹血糖无明显变化(P>0.05)。前列地尔和灯盏细辛治疗的总有效率为93.3%,无药物不良反应发生。结论脑梗死并糖尿病患者血清Hcy水平明显升高,前列地尔和灯盏细辛可通过降低血清Hcy水平来改善患者症状,且无药物不良反应。Objective To investigate effects of Prostaglandin combined with Erigeron Breviscapus on serum homocysteine level in treatment of diabetic patients with cerebral infarction and its effects on the disease. Methods A total of 45 diabetic patients with cerebral infarction （treatment group） admitted during September 2014 and September 2015 were treated with Prostaglandin combined with Erigeron Breviscapus for 2 weeks, and another 42 healthy person taking medical examination at the same period were chosen as control group. Serum homocysteine （Hcy） and fasting plasma glucose （FPG） level changes and incidence rate of hyperhomocysteinemia were compared in two groups, and curative effect and adverse drug reaction treated by Prostaglandin and Erigeron Breviscapus were observed too. Results Compared with those in control group, serum Hcy and FPG levels, and incidence rate of hyperhomocysteinemia were significantly increased before and after treatment in treatment group （P 〈 O. 05 ）. Compared with those before treatment, serum Hcy level and incidence rate of hyperhomocysteinemia were significantly decreased （P 〈 0.05） , while FPG level showed no significant change after treatment in treatment group （P 〉 0. 05）. The total effective rate of Prostaglandin and Erigeron Breviscapus was 93.3% , and no adverse drug reaction was found. Conclusion Serum Hcy levels of diabetic patients with cerebral infarction are significantly increased, and Prostaglandin and Erigeron Breviscapus can improve symptoms of patients by decreasing serum Hcy level without adverse drug reaction.

关 键 词：糖尿病 脑梗死 同型半胱氨酸 前列地尔 灯盏细辛 

分 类 号：R743.33[医药卫生—神经病学与精神病学] R587.1[医药卫生—临床医学]