益生菌联合美沙拉嗪治疗轻、中度活动期溃疡性结肠炎的效果及安全性  

The Efficacy and Safety of Probiotics Combined with Mesalamine in the Treatment of Mild to Moderate Active Ulcerative Colitis

作　　者：李开学[1] 曾理[1] 舒晴[1] LI Kai-xue ZENG Li SHU Qing.(The Second People＇s Hospital of Shenzhen City , Shenzhen518035, China)

机构地区：[1]广东省深圳市第二人民医院,广东深圳518035

出　　处：《中国医学创新》2017年第8期56-59,共4页Medical Innovation of China

摘　　要：目的:探讨分析益生菌(双歧三联活菌)联合美沙拉嗪治疗轻、中度活动期溃疡性结肠炎的临床效果及安全性。方法:选择本院收治的51例轻、中度溃疡性结肠炎患者作为本次研究对象,按随机数字表法分成联合组(n=26)和对照组(n=25)。其中联合组患者予以美沙拉嗪、双歧三联活菌(口服),对照组患者仅予以美沙拉嗪(口服)。治疗2个月后比较两组患者的临床表现、疾病活动指数(DAI)、内镜下评分、不良反应事件、治疗效果及多种检查指标的差异。结果:联合组的治疗总有效率为88.46%,明显高于对照组的76.00%,差异有统计学意义(P<0.05);两组患者治疗前的临床症状总分、疾病活动指数、内镜下评分、血沉、C-反应蛋白、TNF-α、IL-17及IL-23等指标比较,差异均无统计学意义(P>0.05);治疗后,联合组患者的临床症状总分、疾病活动指数、内镜下评分、血沉、C-反应蛋白、TNF-α、IL-17及IL-23等指标均低于对照组,差异均有统计学意义(P<0.05);而两组患者的药物不良反应发生率比较,差异无统计学意义(P>0.05)。结论:益生菌联合美沙拉嗪治疗轻、中度活动期溃疡性结肠炎能够明显改善患者的临床症状,缓解活动期溃疡性结肠炎的炎症反应,具有良好的临床治疗效果及安全性。Objective： To study and analyze the clinical efficacy and safety of Probiotics （ Bifidobacterium ） combined with Mesalamine in the treatment of mild to moderate active ulcerative colitis.Method： A total of 51 patients of mild to moderate ulcerative colitis treated in our hospital were selected as research objects, and they were divided into two groups according to the random number table method.The combination group （ n=26 ） was given Mesalazine and Probiotics, and the control group （ n=25 ） was only given Mesalazine.Mter two months, the differences of the clinical manifestations, disease activity index （ DAI ）, endoscopic score, adverse events, the treatment effect and various clinical parameters of two groups were compared.Result： The total effective rate of the combination group （ 88.46% ） was obviously higher than 76.00% of the control group, and the difference was statistically significant （ P〈0.05 ） . Before treatment, the differences of the clinical symptom scores, DAI, endoscopic grade, blood sedimentation, C-reactive protein, TNF-α , IL-17 and IL-23 values between two groups didn＇t have Statistical significance （ P〉0.05 ） .After treatment, the clinical symptom scores, DAI, endoscopic grade, blood sedimentation, C-reactive protein, TNF- α, IL-17 and IL-23 values of the combination group were lower than those of the control group, and the differences were statistically significant （ P〈0.05 ）, and the differences of drug adverse incidence of two groups didn＇t have statistical significance （P〉0.05） .Conclusion： It can obviously relieve patient＇s clinical symptoms of Probiotics combined with Mesalamine in the treatment of mild to moderate ulcerative colitis, and reduce the inflammatory response in active ulcerative colitis, so the therapy has a better efficacy and safety.

关 键 词：益生菌 美沙拉嗪 溃疡性结肠炎 效果 安全性 

分 类 号：R574.62[医药卫生—消化系统]