应用静息态功能磁共振成像分数低频振幅技术研究中高度近视患者大脑活动的异常改变  

A resting-state fMRI study on brain functional activity changes in moderate and high myopia patients using fractional amplitude of low frequency fluctuation

作　　者：胡裕翔 周荃[1] 李宇平 许晓璇[1] 吴一凡[3] 刘克政[1] 占敏艳[1] 吴晓蓉[1] HU Yu-Xiang ZHOU Quan LI Yu-Ping XU Xiao-Xuan WU Yi-Fan LIU Ke-Zheng ZHAN Min-Yan WU Xiao- Rong

机构地区：[1]南昌大学第一附属医院眼科,江西省南昌市330006 [2]东乡县人民医院眼科,江西省抚州市331800 [3]湘南学院,湖南省郴州市423000

出　　处：《眼科新进展》2017年第3期239-243,共5页Recent Advances in Ophthalmology

基　　金：国家自然科学基金资助(编号:81360151);江西省科技支撑计划项目(编号:20141BBG70027);江西省教育厅科技计划项目(编号:GJJ13147);江西省卫计委科技计划项目(编号:20141031);2012年江西省远航工程;2016年南昌大学研究生创新专项资金(编号:cx2016307)~~

摘　　要：目的利用静息态功能磁共振成像中的分数低频振幅(fractional amplitude of low frequency fluctuation,fALFF)技术研究中高度近视患者的脑功能改变,探讨其与近视患者临床资料的相关性。方法选择21例中高度近视患者为近视组,选择21名年龄、性别相匹配的健康志愿者为正常对照组,对入选者行静息态功能磁共振fALFF扫描。比较近视组与正常对照组大脑功能活动fALFF值的差异,并且分析fALFF改变的脑区与近视患者临床资料的相关性。结果相比于正常对照组,近视组在左侧额下回、壳核与右侧额下回、壳核、岛叶等区域fALFF值显著减低(均为P<0.05),然而双侧中扣带回、双侧前扣带回、左侧中央后回以及左侧顶上小叶等区域fALFF值显著增高(均为P<0.05)。在近视组中,患者大脑不同区域的平均fALFF值与其病程、屈光度及最佳矫正视力均无明显相关性(均为P>0.05)。结论近视患者伴随着多个脑区的神经元活动异常,这些脑区异常可能反映近视患者在语言理解和注意力控制方面可能存在功能障碍。Objective To investigate the changes of brain function in moderate and high myopia patients using fractional amplitude of low frequency fluctuation （fALFF）,and discuss the correlation between brain function changes and clinical data of patients with myopia.Methods Totally 21 moderate and high myopia patients （myopia group）,and 21 healthy volunteers （normal control group） who were matched with myopia patients in age and gender,were selected to take rs-fMRI examination.The difference of fALFF of brain functional activity in patients with myopia and normal controls was compared,and the correlation between the changes of fALFF and clinical data of patients with myopia was analyzed.Results Compared with normal control group,the fALFF values of myopia group in the region of the left inferior frontal gyrus,putamen and right inferior frontal gyrus,putamen and insula were significantly lower （all P〈0.05,AlphaSim corrected）.However,in bilateral cingulate gyrus,bilateral anterior cingulate gyrus,left postcentral gyrus,left superior parietal lobule and region,fALFF values were increased （all P〈0.05,AlphaSim corrected）.Conclusion Patients with myopia are accompanied by abnormal neuronal activity in many brain areas,which may reflect the dysfunction of language understanding and attention control in myopic patients.

关 键 词：近视 静息态功能磁共振成像 分数低频振幅 

分 类 号：R770.4[医药卫生—眼科]