脉络膜新生血管抑制剂最新研究进展  

Research advances in inhibitors for choroid neovascularization

作　　者：罗丹[1] 金明[1] LUO Dan JIN Ming

机构地区：[1]中日友好医院眼科,北京市100029

出　　处：《眼科新进展》2017年第3期285-288,共4页Recent Advances in Ophthalmology

基　　金：国家自然科学基金资助(编号:81373693)~~

摘　　要：脉络膜新生血管是脉络膜血管病理性增生表现,易伴发出血及渗出,是致盲的主要因素之一。目前针对脉络膜新生血管的治疗成为了研究热点,并且在血管内皮生长因子及其受体抑制剂、内源性血管生成因子抑制剂、氧化还原和炎症反应相关因子抑制剂等研究上取得了一定进展,有关此病的中药治疗也取得相应成就。本文就脉络膜新生血管抑制剂最新研究进展展开综述。Choroid neovascularization （CNV） is pathological proliferation of choroid vascular, accompanying with bleeding and leakage, is one of the major factors caused blindness, so CNV inhibitors have become a research hotspot. At present, researches on inhibitors of vascular endothelial growth factors and their receptors, endogenous angiogenesis factors ,redox and inflammatory response related factors, etc ,have achieved certain progresses. In addition, as drugs with multiple targets for treatment, many Chinese herbs also show inhibition effect on CNV. This article reviews the research advances in inhibitors for CNV.

关 键 词：脉络膜新生血管 血管内皮生长因子 血管内皮生长因子受体 氧化还原 炎症 

分 类 号：R773.4[医药卫生—眼科]