长链非编码RNA LOC285194在乳腺癌组织中的表达及临床意义  

Expression and clinical significance of long chain non-coding RNA LOC285194 in human breast cancer tissue

作　　者：黄秋霞[1] 陈罡[1] 冯震博[1] 韦康来[1] 陈皓[1] Huang Qiuxia Chen Gang Feng Zhenbo Wei Kanglai Chen Hao(Department of Pathology ,First Affiliated Hospital of Guangxi Medical University, Nanning ,C, uangxi 530021 ,China)

机构地区：[1]广西医科大学第一附属医院病理科,南宁535021

出　　处：《重庆医学》2017年第9期1223-1225,共3页Chongqing medicine

摘　　要：目的探讨长链非编码RNA(lncRNA)LOC285194在乳腺癌及癌旁组织中的表达及其临床意义。方法选取石蜡包埋的乳腺癌组织42份及癌旁组织16份,用实时荧光定量PCR技术检测lncRNA LOC285194的表达,分析其与临床病理特征的相关性。结果 lncRNA LOC285194在乳腺癌组织中表达水平明显低于癌旁组织(P<0.01);lncRNA LOC285194在人类表皮生长因子受体2(HER2)过表达乳腺癌组织较HER2阴性乳腺癌组织表达水平上调(P=0.013),二者呈正相关(r=0.385,P=0.012)。结论 lncRNA LOC285194可能在乳腺癌起抑癌基因的作用,可能是通过与HER2的关联参与乳腺癌的发生,其有可能成为乳腺癌治疗的靶基因。Objective To investigate the expression of long chain non-coding（lnc）RNA LOC285194 in breast cancer tissue and paracancerous tissue and its clinical significance.Methods Forty-two samples of paraffin embedded breast cancer tissue and 16 samples of paraffin embedded paracancerous tissue were selected.The expression of lncRNA LOC285194 in these tissue were detected by using quantitative real-time polymerase chain reaction（PCR）.Then its correlation with clinicopathological features was analyzed.Results The expression level of lncRNA LOC285194 in breast cancer tissue was significantly lower that in the paracancerous tissue（P〈0.01）;the level of lncRNA LOC285194 in human epidermal growth factor receptor-2（HER2）overexpression tissues was up-regulated compared with HER2 negative breast cancer tissue（P=0.013）,there was a positive correlation between them（r=0.385,P=0.012）.Conclusion lncRNA LOC285194 may play the role of cancer suppressor gene and may be involved in the generation of breast cancer by HER2 association,which may become a target gene of breast cancer treatment.

关 键 词：乳腺肿瘤 长链非编码RNA LOC285194 肿瘤发生 人类表皮生长因子受体2 

分 类 号：R737.9[医药卫生—肿瘤]