T细胞共刺激分子及其亚群在胃癌和大肠癌组织中表达的意义  

Significance of T Cell Co-stimulatory Molecules and Their Subgroups in the Expression of Gastric Carcinoma and Colorectal Cancer Tissues

作　　者：高旭[1] 陈维荣[1] 蔡高阳[1] 李彦冲[1] 林凯煌[1] 

机构地区：[1]汕头大学医学院第二附属医院普外科,广东汕头515000

出　　处：《中外医疗》2017年第4期3-5,共3页China & Foreign Medical Treatment

摘　　要：目的探讨和分析T细胞共刺激分子及其亚群在胃癌和大肠癌组织中表达的意义。方法该次研究选择该院于2014年9月—2016年10月期间收治的41例胃癌患者和39例大肠癌患者作为研究主体,胃癌患者为甲组,大肠癌患者为乙组,选择同期进行检测的33名健康人作为丙组。对入院的人群通过流式细胞术进行检测,对比3组T细胞共刺激分子及其亚群的检测结果。结果甲乙两组T细胞共刺激分子CD28+CD3+水平[(25.81±10.55)、(28.94±9.28)%]高于丙组[(0.81±0.97)%],甲乙两组T细胞CD3+水平[(53.62±13.83)、(55.95±10.67)%]低于丙组[(72.06±7.82)%],甲乙两组T细胞CD4+CD3+水平[(29.83±9.72)、(33.74±9.03)%]低于丙组[(38.78±5.07)%],甲乙两组T细胞CD8+CD28+CD3+水平[(1.58±1.98)、(1.92±2.62)%]高于丙组[(0.04±0.03)%],甲组T细胞CD8+CD28-CD3+[(16.07±6.95%)]以及CD4/CD8水平[(1.15±0.54)%]低于丙组[(20.55±6.55)、(1.35±0.32)%],乙组T细胞CD4+CD25+CD3+水平[(19.75±6.88)%]高于丙组[(13.71±3.07)%],差异有统计学意义(P<0.05)。甲乙两组术前术后除CD3+和CD28+CD3-之外的T细胞亚群差异无统计学意义(P>0.05)。结论大肠癌患者以及胃癌患者的T细胞数量显著减少,而T细胞共刺激分子(CD28)的表达增高,在胃癌患者中CD4+T细胞数量明显减少,而在大肠癌患者中调节性T细胞数量明显增加。Objective To discuss and analyze the significance of T cell co-stimulatory molecules and their subgroups in the expression of gastric carcinoma and colorectal cancer tissues. Methods 41 cases of patients with gastric carcinoma and 39 cases of patients with colorectal cancer treated in our hospital from September 2014 to October 2016 were selected as the research objects and the patients with gastric carcinoma were selected as the group A, while the patients with colorectal cancer were selected as the group B, and 33 cases of healthy persons at the same period were selected as the group C, and the admission persons were tested by the Flow cytometry, and test results of T cell co-stimulatory molecules and their subgroups of the three groups were compared. Results The T cell co-stimulatory molecule CD28＋CD3＋ level in the group A and group B was higher than that in the group C[（25.81±10.55）,（28.94±9.28）% vs（0.81±0.97）%], and T cell CD3＋ level in the group A and group B was higher than that in the group C [（53.62±13.83）,（55.95±10.67）% vs（72.06±7.82）%],the T cell CD4＋CD3＋ level in the group A and group B was lower than that in the group C[（29.83±9.72）,（33.74±9.03）% vs（38.78±5.07）%], the T cell CD8＋CD28＋CD3＋ level in the group A and group B was higher than that in the group C, [（1.58±1.98）%,1.92±2.62）% vs（0.04±0.03）%],the T cell CD8＋CD28-CD3＋ and CD4/CD8 levels in the group A was lower than that in the group C[（16.07±6.95）,（1.15±0.54）%vs（20.55±6.55）,（1.35±0.32）%], and the T cell CD4＋CD25＋CD3＋ level in the group B was higher than that in the group C[（19.75±6.88）% vs（13.71±3.07）%], and the difference had statistical significance（P〈0.05）, and the differences in T cell subgroups except for CD3＋ and CD28＋CD3-before and after operation in the group A and group B had no statistical significance（P〈0.05）. Conclusion The T cell number of patients with gastric carcinoma and colorectal cancer obviously d

关 键 词：T细胞共刺激分子 T细胞亚群 胃癌 大肠癌 

分 类 号：R735[医药卫生—肿瘤]