香菇多糖注射液不同疗程给药对奥沙利铂联合卡培他宾治疗胃癌效果及对患者外周血CEA、CA199水平的影响  

Effect of lentinan injection in different treatment administration of oxaliplatin combined with capecitabine in gastric cancer and the effect on the peripheral blood of patients with CEA and CA199 levels

作　　者：章跃 罗雨[2] 徐新亚[3] 

机构地区：[1]诸暨市人民医院药剂科,浙江诸暨311800 [2]湖北工业大学生物工程与食品学院,湖北武汉430070 [3]杭州市中医院肿瘤科,浙江杭州330100

出　　处：《中国生化药物杂志》2017年第3期78-80,共3页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的 探讨香菇多糖注射液不同疗程给予对奥沙利铂联合卡培他宾治疗胃癌效果及对患者外周血癌胚抗原（CEA）、糖类抗原（CA-199）水平的影响。方法 选取2009年9月~2012年9月间诸暨市人民医院肿瘤科收治的90例患者作为研究对象,根据患者使用香菇多糖注射液疗程不同,将患者分为分为A、B、C 3组,随访3组患者化疗不良反应及化疗效果,并检测患者血清CEA、CA-199水平。结果 A组患者完全缓解（CR）、部分缓解（PR）、稳定（SD）、疾病进展（PD）例数分别为12、7、8、3例,客观有效率（RR）为63.3%,明显优于B、C 2组,差异有统计学意义（P〈0.05）;A组患者白细胞减少Ⅰ、Ⅱ、Ⅲ度分别为15、10、5例;胃肠道反应Ⅰ、Ⅱ、Ⅲ度分别为12、10、8例;肝功能异常Ⅰ、Ⅱ、Ⅲ度分别为14、9、7例。A组白细胞减少、胃肠道、肝功能异常异常程度病变程度低于B组、C组,差异有统计学意义（P〈0.05）;治疗前CEA、CA199水平对比无差异,化疗1疗程、2疗程后A、B、C3组组患者CEA、CA199水平均较治疗前下降,且A组水平明显低于B、C 2组,B、C 2组之间无明显差异。结论 香菇多糖注射液有助于提高胃癌患者化疗的敏感性、降低化疗不良反应,降低肿瘤标志物水平,改善胃癌患者预后。Objective To investigate the effect of lentinan injection in different treatment administration of oxaliplatin combined with capecitabine in treatment of gastric cancer and the effect on the peripheral blood of patients with CEA and CA199 levels.Methods 90 cases in our hospital from September 2009 to September 2012 were selected as research subjects, according to patients with lentinan injection treatment, the patients were divided into A, B and C three groups, the effect and the adverse effects of chemotherapy in three groups of patients, detection of serum CEA and CA-199 levels. Results CR, PR, SD and PD of A groups were 12, 7, 8, 3 cases, RR was 63.3%, obviously higher than that of B, C two groups, the difference was statistically significant （P〈0.05）, group A patients with leukopenia I,II and III degree were 15, 10, 5 cases of gastrointestinal reaction, I, II, III were 12, 10, 8 cases of abnormal liver function, I, II and III degree were 14, 9, 7 cases.A group, leukopenia, gastrointestinal tract, liver function abnormal lesion was lower than the B group and C group, the difference was statistically significant （P〈0.05）, CEA, CA199 level before treatment compared to no difference, one course of chemotherapy, after two courses of A, B, C three groups of patients with CEA and CA199 level were before treatment decreased, and the level of group A was significantly lower than that of B, C two B, C group, no significant difference between the two groups. Conclusion Lentinan injection helps to improve the sensitivity of chemotherapy in patients with gastric cancer, reduce adverse drug reactions, reduce the level of tumor markers, improve the prognosis of patients with gastric cancer.

关 键 词：香菇多糖注射液 奥沙利铂 卡培他宾 胃癌 CEA CA199 

分 类 号：R735.2[医药卫生—肿瘤]