丹芍疏肝颗粒联合二甲双胍对非酒精性脂肪肝患者糖、脂、尿酸代谢的影响  

Effect of Danshao Shugan granule combined with metformin in treatment of nonalcoholic fatty liver and its effects on lipid and uric acid metabolism

作　　者：马鲜霞 褚建平[2] 蒋琦[3] 

机构地区：[1]慈溪市第三人民医院,浙江慈溪315324 [2]宁波市第一医院内分泌科,浙江宁波315010 [3]宁波市第一医院消化内科,浙江宁波315010

出　　处：《中国生化药物杂志》2017年第3期104-106,共3页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的 研究丹芍疏肝颗粒联合二甲双胍对非酒精性脂肪肝患者糖、脂、尿酸代谢的影响。方法 选取2014年2月~2015年2月慈溪市第三人民医院接诊的80例非酒精性脂肪肝患者,按照随机数表法分为观察组和对照组,各40例,对照组采用二甲双胍治疗,观察组采用丹芍疏肝颗粒联合二甲双胍治疗。观察2组患者治疗后血脂水平,FBG、FINS、IR、SUA水平,SOD、MDA水平,比较2组治疗效果。结果 治疗后,观察组TG、TC显著低于对照组（P〈0.05）;观察组FBG、FINS、IR、SUA水平明显低于对照组（P〈0.05）;观察组SOD水平显著高于对照组,MDA水平低于对照组（P〈0.05）;观察组总有效率明显高于对照组（P〈0.05）。结论丹芍疏肝颗粒联合二甲双胍对非酒精性脂肪肝疗效显著,能够改善患者糖、脂、尿酸代谢以及胰岛素抵抗,具有保护肝功能的作用。Objective To study the effect of danshao shugan granule combined with metformin in treatment of nonalcoholic fatty liver and its effects on lipid and uric acid metabolism.Methods 80 patients of nonalcoholic fatty liver who received therapy from February 2014 to February 2015 in our hospital were selected as research objects.According to random number table,those patients were divided into the observation group （n=40） cases in each group and the control group （n=40）.The control group was treated with metformin, while the observation group was treated with danshao shugan granule combined with metformin.Then blood lipid level, FBG, FINS, IR, SUA level, SOD, MDA level, therapeutic effect of two groups after treatment were compared.Results After treatment, TG,TC in observation group was significantly less than the control group （P〈0.05）; FBG, FINS, IR, SUA levels in the observation group were significantly lower than the control group （ P〈0.05 ）; SOD level higher than the control group, MDA level significantly less than the control group （P〈0.05）; The total effective rate of observation group was statistically higher than that in the control group （P〈0.05）.Conclusion Danshao shugan granule combined with metformin is well for nonalcoholic fatty liver,which can improve the glucose, lipid, uric acid metabolism and insulin resistance, and can protect the liver function.

关 键 词：丹芍疏肝颗粒 二甲双胍 非酒精性脂肪肝 血尿酸 胰岛素抵抗 

分 类 号：R575.5[医药卫生—消化系统]