盐酸米诺环素软膏联合布洛芬对慢性牙周炎患者血清因子浓度的影响  

Effect of minocycline hydrochloride ointment combined with ibuprofen on serum concentration in chronic periodontitis

作　　者：姚旭飞[1] 季育[1] 

机构地区：[1]丽水市中医院口腔科

出　　处：《中国生化药物杂志》2017年第3期184-186,共3页Chinese Journal of Biochemical Pharmaceutics

基　　金：浙江省医药卫生一般研究计划(2015KYB205)

摘　　要：目的 研究盐酸米诺环素软膏联合布洛芬对慢性牙周炎患者血清因子浓度的影响。方法 选取2014年6月～2016年6月于丽水市中医院接受治疗的慢性牙周炎患者86例,将患者随机分为2组：观察组43例,使用盐酸米诺环素软膏结合布洛芬治疗;对照组43例,只使用盐酸米诺环素软膏进行治疗。治疗后观察2组患者的临床疗效,记录患者治疗前后菌斑的指标、附着的水平、牙龈沟出血的指标和牙周袋的探诊深度,检测血清白细胞介素-10（interleukin-10,IL-10）、肿瘤坏死因子-α（tumor necrosis factor-α,TNF-α）、超敏C反应蛋白（hypersensitive C-reactive protein,hs-CRP）和白细胞介素-8（interleukin-8,IL-8）的含量和发生的不良反应情况。结果 治疗后观察组患者的总有效率为90.7%,对照组患者的总有效率为74.4%,观察组明显高于对照组,差异有统计学意义（P〈0.05）;治疗前后2组患者牙周袋探诊深度、牙龈沟出血指数、附着水平和菌斑指数都有不同程度的降低,差异均有统计学意义（P〈0.05）,观察组患者比对照组患者降低的更多,差异有统计学意义（P〈0.05）;治疗后2组患者血清中IL-8、hs-CRP和TNF-α的含量有不同程度的下降,IL-10的含量有不同程度的上升,差异均有统计学意义（P〈0.05）,观察组患者效果优于对照组,差异有统计学意义（P〈0.05）。结论 盐酸米诺环素软膏联合布洛芬对慢性牙周炎患者取得了较好的疗效,可有效缓解患者的病情,改善患者血清因子的浓度。Objective To study the effect of minocycline hydrochloride ointment and ibuprofen on serum concentration of chronic periodontitis . Methods 86 patients with chronic periodontitis treated in our hospital from June 2014 to June 2016 were selected and randomly divided into two groups：observation group 43 cases, using minocycline hydrochloride ointment combined with ibuprofen treatment , the control group 43 cases, only the use of minocycline hydrochloride ointment for treatment.After treatment, the clinical efficacy of the two groups were observed, the level of plaque, the level of attachment, the level of gingival sulcus bleeding and the probing depth of periodontal pocket were recorded, the levels of IL-10, TNF-α, hs-CRP and IL-8 in serum and the incidence of adverse reactions were measured.Results The total effective rate was 90.7% in the observation group and 74.4%in the control group, which was significantly higher than that in the control group, the difference was statistically significant （P〈0.05）.The probing depth of the periodontal pocket, gingival sulcus bleeding index, attachment level and plaque index decreased to varying degrees in the two groups before and after treatment, the difference was statistically significant （P〈0.05）, patients in the observation group were significantly lower than those in the control group, the difference was statistically significant （P〈0.05）.After treatment, the levels of IL-8, hs-CRP and TNF-αin serum of the two groups decreased, IL-10 levels increased in different degrees, the difference was statistically significant （P〈0.05）.The observation group was better than the control group, the difference was statistically significant （ P〈0.05 ） .Conclusion Minocycline hydrochloride ointment combined with ibuprofen has a good effect on patients with chronic periodontitis.It can effectively relieve the patient＇s condition and improve the serum concentration of patients.

关 键 词：盐酸米诺环素软膏 布洛芬 联合 慢性牙周炎 

分 类 号：R781.4[医药卫生—口腔医学]