富马酸依美斯汀联合普拉洛芬滴眼液治疗过敏性结膜炎的临床疗效及对患者相关指标的影响  

Clinical efficacy of emedastine difumarate combined with pranoprofen eye drops in allergic conjunctivitis and its influence on related indicators

作　　者：孙亮亮 章征[2] 吴爱华 

机构地区：[1]舟山市普陀区人民医院眼科,浙江舟山316100 [2]浙江大学医学院附属第二医院眼科,浙江杭州310009 [3]舟山医院眼科,浙江舟山316000

出　　处：《中国生化药物杂志》2017年第3期219-221,共3页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的 探讨富马酸依美斯汀联合普拉洛芬治疗过敏性结膜的临床疗效分析及对患者组胺（histamine,HA）、嗜酸粒细胞阳离子蛋白（eosinophil cationic protein,ECP）、白三烯B4（leukotrienes B4,LTB4）及IgE影响,为临床的诊断治疗提供参考。方法 76例过敏性结膜炎患者按照随机数字表法将其分为对照组和实验组,对照组采用富马酸依美斯汀滴眼液进行治疗,实验组采用富马酸依美斯汀联合普拉洛芬滴眼液进行治疗,比较2组患者疗效及血清中相关指标的水平。结果 实验组总有效率显著优于对照组（94.70%vs.81.60%）（P〈0.05）。治疗后,实验组的血清ECP、HA、LTB4、IgE均显著低于对照组（P〈0.05）。结论 富马酸依美斯汀联合普拉洛芬治疗过敏性结膜炎治疗效果优于单一用药,并且ECP、HA、LTB4、IgE等指标明显降低。Objective To evaluate the clinical effect of emedastine difumarate eye drops combined with pranoprofen eye drops on histamine （HA）, eosinophil cationic protein （ECP）, leukotrienes B4（LTB4） and, IgE levels of allergic conjunctival and provide reference for clinical diagnosis and treatment.Methods 76 cases of patients with allergic conjunctivitis were randomly divided into control group and experimental group , control group were treated with fumaric acid emedastine eye drops, experimental group were treated with fumarate emedastine combined with pranoprofen eye drops, and then compare the efficacy and serum ECP, HA, LTB4 and IgE levels between two groups before and after treatment of the symptoms and signs score . Results The total efficacy of experimental group was significantly higher than that in control group （94.70%vs.81.60%）（P〈0.05）.The serum ECP, HA, LTB4 and IgE levels of experimental group were significantly lower than those in control group（P〈0.05）.Conclusion The emedastine difumarate combined with pranoprofen eye drops in the treatment of allergic conjunctivitis is better than single medication, and ECP, HA, LTB4, IgE significantly decrease.

关 键 词：富马酸依美斯汀滴眼液 普拉洛芬滴眼液 过敏性结膜炎 组胺 嗜酸粒细胞阳离子蛋白 白三烯B4 IGE 

分 类 号：R777.31[医药卫生—眼科] R781.67[医药卫生—临床医学]